Citrate pharmacokinetics in critically ill liver failure patients receiving CRRT (2022)
Title : Citrate pharmacokinetics in critically ill liver failure patients receiving CRRT
Researcher : Thanapongsatorn, P., Chaijamorn, W.,[mfn]1[/mfn] Sirivongrangson, P., …Lucksiri, A., Srisawat, N.
Department : 1Faculty of Medicine, Siam University, Bangkok, Thailand
Abstract : Citrate has been proposed as anticoagulation of choice in continuous renal replacement therapy (CRRT). However, little is known about the pharmacokinetics (PK) and metabolism of citrate in liver failure patients who require CRRT with regional citrate anticoagulation (RCA). This prospective clinical PK study was conducted at King Chulalongkorn Memorial Hospital between July 2019 to April 2021, evaluating seven acute liver failure (ALF) and seven acute-on-chronic liver failure (ACLF) patients who received CRRT support utilizing RCA as an anticoagulant at a citrate dose of 3 mmol/L. For evaluation of the citrate PK, we delivered citrate for 120 min and then stopped for a further 120 min. Total body clearance of citrate was 152.5 ± 50.9 and 195.6 ± 174.3 mL/min in ALF and ACLF, respectively. The ionized calcium, ionized magnesium, and pH slightly decreased after starting citrate infusion and gradually increased to baseline after stopping citrate infusion. Two of the ACLF patients displayed citrate toxicity during citrate infusion, while, no ALF patient had citrate toxicity. In summary, citrate clearance was significantly decreased in critically ill ALF and ACLF patients receiving CRRT. Citrate use as an anticoagulation in these patients is of concern for the risk of citrate toxicity.
Link to Academic article: https://www.nature.com/articles/s41598-022-05867-8
Bibliography : Thanapongsatorn, P., Chaijamorn, W., Sirivongrangson, P., Tachaboon, S., Peerapornratana, S., Lumlertgul, N.,…Srisawat, N. (2022). Citrate pharmacokinetics in critically ill liver failure patients receiving CRRT. , 12(1), 1815.
Doripenem dosing regimens in Asian critically ill patients with continuous renal replacement therapy (2019)
Title : Doripenem dosing regimens in Asian critically ill patients with continuous renal replacement therapy (2019)
Researcher : Chaijamorn, W., Puchsaka, P.W., Pattharachayakul, S., …Boonpeng, A., Pummangura, C.
Abstract : Antibiotic dosing in critically ill patients with continuous renal replacement therapy (CRRT) is still challenging. Pharmacokinetic changes in critically ill patients such as increased volume of distribution and decreased protein binding affinity affect hydrophilic drug dosing regimens [1]. Consequently, we might prescribe inadequate doses of antimicrobial agents in patients with CRRT [1] which can affect the morbidity and mortality associated with sepsis [2]. Requirement of loading dose and higher maintenance doses for this group of patients has been suggested to achieve pharmacokinetic and pharmacodynamic targets [3].
Continuous renal replacement therapy has been utilizing to effectively remove fluid and waste products in this group of patients due to hemodynamic instability [4]. Doripenem is a water-soluble carbapenem antibiotic and commonly used for Gram negative infection in intensive care unit (ICU) [5]. It can be removed by CRRT due to small molecular weight (438.52 Da) and low volume of distribution (16.8 L) [6].
The recommended dosing regimens from clinical resources are mostly from the pharmacokinetic studies in Western patients and there were a few studies conducted in Asian population [[7], [8], [9], [10], [11], [12]]. No suggested doripenem dosing regimens for CRRT patients based on Asian pharmacokinetic parameters exists. This study aimed to define the optimal doripenem dosing regimens using pharmacokinetic parameters from Asian population and body weights of Asian critically ill patients and to evaluate the probability of target attainment (PTA) of recommended dosing regimens from available clinical resources.
Link to article: https://doi.org/10.1016/j.jcrc.2019.04.030
Journal : ,
Bibliography : Chaijamorn, W., Puchsaka, P., Pattharachayakul, S., Charoensareerat, T., Srisawat, N., Boonpeng, A., & Pummangura, C. (Doripenem dosing regimens in Asian critically ill patients with continuous renal replacement therapy.
Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations (2021)
Title : Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations
Researcher : Dhakrit Rungkitwattanakul, Taniya Charoensareerat, Pathakorn Kerdnimith, Nutsinee Kosumwisaisakul, Piyakamol Teeranaew, Apinya Boonpeng, Sutthiporn Pattharachayakul, Nattachai Srisawat and Weerachai Chaijamorn
Link to article: Renal Replacement Therapy Vol. 7, Article number: 61 (2021) Page.1-11. https://doi.org/10.1186/s41100-021-00380-6
Citation : Rungkitwattanakul D., Charoensareerat T., Kerdnimith P., Kosumwisaisakul N., Teeranaew P.,Boonpeng A…Chaijamorn W. (2021). Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: Systematic review and Monte Carlo simulations. Renal Replacement Therapy, 7(61), 1-11. https://doi.org/10.1186/s41100-021-00380-6
Journal : Renal Replacement Therapy / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/imipenem-dosing-recommendations-for-patients/
Lacosamide dosing in patients receiving continuous renal replacement therapy (2023)
Title : Lacosamide dosing in patients receiving continuous renal replacement therapy
Researcher : Weerachai Chaijamorn, Sathian Phunpon, Thanompong Sathienluckana, Taniya Charoensareerat, Sutthiporn Pattharachayakul, Dhakrit Rungkitwattanakul and Nattachai Srisawat
Link to article: Journal of Intensive Care, Volume 11, Issue 50, pages 1-9. https://doi.org/10.1186/s40560-023-00700-4
Citation : Chaijamorn W, Phunpon S, Sathienluckana T, Charoensareerat T, Pattharachayakul S, Rungkitwattanakul D and Srisawat N. (2023). Lacosamide dosing in patients receiving continuous renal replacement therapy. Journal of Intensive Care, 11(50), 1-9. https://doi.org/10.1186/s40560-023-00700-4
Journal : Journal of Intensive Care / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/lacosamide-dosing-in-patients/
Levetiracetam dosing in patients receiving continuous renal replacement therapy (2021)
Title : Levetiracetam dosing in patients receiving continuous renal replacement therapy
Researcher : Weerachai Chaijamorn, Taniya Charoensareerat, Dhakrit Rungkitwattanakul, Sathian Phunpon, Thanompong Sathienluckana, Nattachai Srisawat & Sutthiporn Pattharachayakul
Link to article: Epilepsia Volume 62, Issue9, September 2021, Pages 2151-2158. https://doi.org/10.1111/epi.16971
Citation : Chaijamorn W., Charoensareerat T., Rungkitwattanakul D., Phunpon S., Sathienluckana T., Srisawat N. & Pattharachayakul S. (2021). Levetiracetam dosing in patients receiving continuous renal replacement therapy. Epilepsia, 62(9), 2151-2158. https://doi.org/10.1111/epi.16971
Journal : Epilepsia / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/levetiracetam-dosing-in-patients/
Optimal Meropenem Dosing Regimens in Patients Undergoing Continuous Renal Replacement Therapy: Systematic Review and Monte Carlo Simulations (2023)
Title : Optimal Meropenem Dosing Regimens in Patients Undergoing Continuous Renal Replacement Therapy: Systematic Review and Monte Carlo Simulations
Researcher : Taniya Charoensareerat, Weerachai Chaijamorn, Pathakorn Kerdnimith, Nutsinee Kosumwisaisakul, Piyakamol Teeranaew, Dhakrit Rungkitwattanakul, Apinya Boonpeng, Nattachai Srisawate & Sutthiporn Pattharachayakul
Link to article: Blood Purification, 2023 May 5, pages 1-13. https://doi.org/10.1159/000529694
Citation : Charoensareerat T., Chaijamorn W., Kerdnimith P., Kosumwisaisakul N., Teeranaew P., Rungkitwattanakul D., Boonpeng A., Srisawate N., & Pattharachayakul S. (2023). Optimal meropenem dosing regimens in patients undergoing continuous renal replacement therapy: Systematic review and monte carlo simulations. Blood Purification, 5, 1-13. https://doi.org/10.1159/000529694
Journal : Blood Purification / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/optimal-meropenem-dosing-regimens/
Piperacillin-tazobactam dosing in anuric acute kidney injury patients receiving continuous renal replacement therapy (2023)
Title : Piperacillin-tazobactam dosing in anuric acute kidney injury patients receiving continuous renal replacement therapy
Researcher : Dhakrit Rungkitwattanakul, Taniya Charoensareerat, Ekanong Chaichoke, Thanakorn Rakamthong, Pitchaya Srisang, Sutthiporn Pattharachayakul, Nattachai Srisawat & Weerachai Chaijamorn
Link to article: Seminars in Dialysis, 2023, 20 February 2023, Pages 1-9. https://doi.org/10.1111/sdi.13148
Citation : Rungkitwattanakul D., Charoensareerat T., Chaichoke E., Rakamthong T., Srisang P., Pattharachayakul S., Srisawat N., Chaijamorn W. (2023). Piperacillin-tazobactam dosing in anuric acute kidney injury patients receiving continuous renal replacement therapy. Seminars in Dialysis, 1-9. https://doi.org/10.1111/sdi.13148
Journal : Seminars in Dialysis / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/piperacillin-tazobactam-dosing/
Recommendations of Gentamicin Dose Based on Different Pharmacokinetic/Pharmacodynamic Targets for Intensive Care Adult Patients: A Redefining Approach (2023)
Title : Recommendations of Gentamicin Dose Based on Different Pharmacokinetic/Pharmacodynamic Targets for Intensive Care Adult Patients: A Redefining Approach
Researcher : Mohammad Yaseen Abbasi, Weerachai Chaijamorn, Kamonthip Wiwattanawongsa, Taniya Charoensareerat, Thitima Doungngern
Link to article : Clinical Pharmacology: Advances and Applications, Volume 2023:15, pages 67-76. https://doi.org/10.2147/CPAA.S417298
Citation : Abbasi M.Y., Chaijamorn W., Wiwattanawongsa K., Charoensareerat T., Doungngern T. (2023). Recommendations of Gentamicin Dose Based on Different Pharmacokinetic/Pharmacodynamic Targets for Intensive Care Adult Patients: A Redefining Approach. Clinical Pharmacology: Advances and Applications, 2023(15), 67-76. https://doi.org/10.2147/CPAA.S417298
Journal : Clinical Pharmacology: Advances and Applications / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/recommendations-of-gentamicin-dose-based/
What is the right gentamicin dose for multiple trauma patients? A Monte Carlo simulation exploration study (2023)
Title : What is the right gentamicin dose for multiple trauma patients? A Monte Carlo simulation exploration study
Researcher : Mohammad Yaseen Abbasi, Kamonthip Wiwattanawongsa, Weerachai Chaijamorn, Taniya Charoensareerat and Thitima Doungngern
Link to article: International Journal of Critical Illness and Injury Science, Volume 13, Issue 3, pages 118-124. https://doi.org/10.4103/ijciis.ijciis_14_23
Citation : Abbasi M.Y., Chaijamorn W., Wiwattanawongsa K., Charoensareerat T., & Doungngern T. (2023). What is the right gentamicin dose for multiple trauma patients? A Monte Carlo simulation exploration study. International Journal of Critical Illness and Injury Science, 13(3), 118-124. Jul–Sep 2023. https://doi.org/10.4103/ijciis.ijciis_14_23
Journal : International Journal of Critical Illness and Injury Science / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/what-is-the-right-gentamicin-dose/