Forced oscillation technique as a predictor for loss of control in asthmatic children (2020)

Title           :  Forced oscillation technique as a predictor for loss of control in asthmatic children

Researcher       : Clin.Prof.Suwat Benjaponpitak 

Department     : Faculty of Medicine, Siam University, Bangkok, Thailand

E-mail                : med@siam.edu

Abstract            :  Background: A reliable objective tool using as a predictor of asthma control status could assist asthma management.

Objective: To find the parameters of forced oscillation technique (FOT) as predictors for the future loss of asthma symptom control.

Methods: Children with well-controlled asthma symptom, aged 6-12 years, were recruited for a 12-week prospective study. FOT and spirometer measures and their bronchodilator response were evaluated at baseline. The level of asthma symptom control was evaluated according to Global Initiative for Asthma.

Results: Among 68 recruited children, 41 children (60.3%) maintain their asthma control between 2 visits (group C-C), and 27 children (39.7%) lost their asthma control on the follow-up visit (group C-LC). Baseline FOT parameters, including the values of respiratory resistance at 5 Hz (R5), respiratory resistance at 20 Hz (R20), respiratory reactance at 5 Hz, area of reactance, %predicted of R5 and percentage of bronchodilator response (%∆) of R5 and R20 were significantly different between C-C and C-LC groups. In contrast, only %∆ of forced vital capacity, forced expiratory volume in 1 second (FEV1), and FEF25%-75% (forced expiratory flow 25%-75%) were significantly different between groups. Multiple logistic regression analysis revealed that %predicted of R5, %∆R5, %predicted of FEV1 and %∆FEV1 were the predictive factors for predicting the future loss of asthma control. The following cutoff values demonstrated the best sensitivity and specificity for predicting loss of asthma control: %predicted of R5=91.28, %∆R5=21.2, %predicted of FEV1=89.5, and %∆FEV1=7.8. The combination of these parameters predicted the risk of loss of asthma control with area under the curve of 0.924, accuracy of 83.8%.

Conclusion: Resistance FOT measures have an additive role to spirometric parameter in predicting future loss of asthma control.

Keywords: Asthma; Frequency of resonance; Reactance; Resistance; Spirometry.

Link to Academic article: DOI: 10.5415/apallergy.2020.10.e3


Journal : Asia Pacific Allergy   Vol.10 No.1 (2020)


Bibliography     : Kreetapirom, P., Kiewngam, P., Jotikasthira, W., Kamchaisatian, W., Benjaponpitak, S., & Manuyakorn, W. (2020, January 17). Forced oscillation technique as a predictor for loss of control in asthmatic children. Asia Pac Allergy, 10(1), e3. doi: 10.5415/apallergy.2020.10.e3. PMID: 32099825; PMCID: PMC7016320.


 

คณะแพทยศาสตร์ มหาวิทยาลัยสยาม

อาคาร เฉลิมพระเกียรติ 19 ชั้น 14

เลขที่ 38 ถนน เพชรเกษม แขวงบางหว้า เขตภาษีเจริญ กรุงเทพฯ 10160

Tel: 02-868-6000 ต่อ 5408 Fax: 02-868-6832 Email: med@siam.edu

Website  : https://med.siam.edu/