Comparison of Efficacy and Safety between Long-Acting Injectable Antipsychotic Monotherapy and Combination of Long-Acting Injectable and Oral Antipsychotics in Patients with Schizophrenia (2021)
Title : Comparison of Efficacy and Safety between Long-Acting Injectable Antipsychotic Monotherapy and Combination of Long-Acting Injectable and Oral Antipsychotics in Patients with Schizophrenia
Researcher : Sathienluckana, T., Tiangpattanawong, P., Chaiyasukthananoan, K., Jittayanan, P., Sawetwangsing, H., Puchsaka, P.
Abstract : Background
Long-acting injectable (LAI) antipsychotics are used as a monotherapy in patients with schizophrenia. However, the combination of LAI and oral antipsychotics is commonly used in clinical practice, despite there being very limited studies investigating the efficacy and safety of this combination compared with LAI antipsychotic monotherapy.
Objective
To study the efficacy and safety of LAI antipsychotic monotherapy compared with the combination of LAI and oral antipsychotics in patients with schizophrenia.
Methods
This study was a retrospective cohort study, which classified eligible patients into two groups: the LAI antipsychotic monotherapy group and the combination of LAI and oral antipsychotic group. The primary outcome was hospitalization between groups. The duration of the study was 2 years.
Results
In total, 86 patients completed the study and were analysed (LAI antipsychotic monotherapy group: n = 25; combination of LAI and oral antipsychotic group: n = 61). There was no significant difference in hospitalization between the two groups (P = 1.000). For other outcomes, there were also no significant differences in both all-cause discontinuation (P = 0.667) and adverse drug reactions (P = 0.732) between the two groups.
Conclusion
The efficacy and safety of LAI antipsychotic monotherapy appeared similar to the combination of LAI and oral antipsychotics in patients with schizophrenia. Therefore, the combination of LAI and oral antipsychotics, which is commonly used in clinical practice, may not be necessary.
Link to article: doi: 10.1155/2021/8403986
Journal : Schizophr Res Treatment
Bibliography : Sathienluckana, T., Tiangpattanawong, P., Chaiyasukthananoan, K., Jittayanan, P., Sawetwangsing, H., & Pummangura, C. (Comparison of Efficacy and Safety between Long-Acting Injectable Antipsychotic Monotherapy and Combination of Long-Acting Injectable and Oral Antipsychotics in Patients with Schizophrenia. this,
Complete Genome Sequence of Neisseria gonorrhoeae Multilocus Sequence Type ST7363 Isolated from Thailand (2021)
Title : Complete Genome Sequence of Neisseria gonorrhoeae Multilocus Sequence Type ST7363 Isolated from Thailand
Researcher : Thitima Cherdtrakulkiat, Thidathip Wongsurawat, Piroon Jenjaroenpun, Sawannee Sutheeworapong, Wanna Leelawiwat, Joseph V. Woodring, Eileen F. Dunne, John R. Papp, Somporn Srifuengfung and Chanwit Tribuddharati
Link to article: Microbiology Resource Announcements Vol.10 No.e00573-21 Page. 1-4. https://doi.org/10.1128/mra.00573-21
Journal : Microbiology Resource Announcements / in Scopus
Citation : Cherdtrakulkiat T., Wongsurawat T., Jenjaroenpun P., Sutheeworapong S., Leelawiwat W., Woodring, Joseph V. , Dunne, Eileen F. , Papp, John R. Srifuengfung S. & Tribuddharati, C. (2021). Complete genome sequence of neisseria gonorrhoeae multilocus sequence type ST7363 isolated from Thailand. Microbiology Resource Announcements, 10(e00573-21), 1-4. https://doi.org/10.1128/mra.00573-21
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/complete-genome-sequence-of-neisseria-gonorrhoeae/
Effect of needle sizes 30 G and 32 G on skin penetration force in cadavers: Implications for pain perception and needle change during botulinum toxin injections (2021)
Title : Effect of needle sizes 30 G and 32 G on skin penetration force in cadavers: Implications for pain perception and needle change during botulinum toxin injections
Researcher : Tansatit, T., Uruwan, S., Wilkes, M., Rungsawang, C.
Abstract : Cosmetic botulinum toxin injections usually cause discomfort to the patient. Using a small needle causes less pain compared to using a large needle,1 but a drawback is the price. A 30-G needle costs 2 THB while a 32-G needle costs 15 THB. The physician must decide when a needle is to be discarded. In one study, a 30-G needle was changed after approximately four to six punctures because of increased skin resistance.2 A 32-G needle is less painful than a 30-G needle because of the 25 percent smaller diameter of the 32-G needle.3 Instead of relying on individual tactile sense, we compared the penetration forces of two needle sizes to decide when to change the needle during botulinum toxin treatment.
Link to Academic article: DOI: 10.1097/PRS.0000000000008558
Journal : ,
Bibliography : Tansatit, T., Uruwan, S., Wilkes, M., & Rungsawang, C. (2021). Effect of needle sizes 30 G and 32 G on skin penetration force in cadavers: Implications for pain perception and needle change during botulinum toxin injections.
Efficacy and Safety of Enteral Erythromycin Estolate in Combination With Intravenous Metoclopramide vs Intravenous Metoclopramide Monotherapy in Mechanically Ventilated Patients With Enteral Feeding Intolerance: A Randomized, Double-Blind, Controlled Pilot Study (2021)
Title : Efficacy and Safety of Enteral Erythromycin Estolate in Combination With Intravenous Metoclopramide vs Intravenous Metoclopramide Monotherapy in Mechanically Ventilated Patients With Enteral Feeding Intolerance: A Randomized, Double-Blind, Controlled Pilot Study
Researcher : Taniya Charoensareerat, Rungsun Bhurayanontachai, Sirima Sitaruno, Asma Navasakulpong, Apinya Boonpeng, Sanguan Lerkiatbundit & Sutthiporn Pattharachayakul
Link to article: Journal of Parenteral and Enteral Nutrition 2021 Aug;45(6):1309-1318. https://doi.org/10.1002/jpen.2013
Citation : Charoensareerat T., Bhurayanontachai R., Sitaruno S., Navasakulpong A., Boonpeng A., Lerkiatbundit S. & Pattharachayakul S.. (2021). Efficacy and safety of enteral erythromycin estolate in combination with intravenous metoclopramide vs intravenous metoclopramide monotherapy in mechanically ventilated patients with enteral feeding intolerance: A randomized, double-blind, controlled pilot study. Journal of Parenteral and Enteral, 45(6), 1309-1318. https://doi.org/10.1002/jpen.2013
Journal : Journal of Parenteral and Enteral Nutrition / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/efficacy-and-safety/
Electrospun nanofibers from natural polymers and their application (2021)
Title : Electrospun nanofibers from natural polymers and their application
Researcher : Nawinda Chinatangkul, Chutima Limmatvapirat and Sontaya Limmatvapirat
Link to article : Science, Engineering and Health Studies (SEHS) Vol. 15(2021) Page.1-11. https://doi.org/10.14456/sehs.2021.29
Citation : Chinatangkul, N., Limmatvapirat, C., & Limmatvapirat, S. (2021). Electrospun nanofibers from natural polymers and their application. Science, Engineering and Health Studies, 15, 21010005. https://doi.org/10.14456/sehs.2021.29
Journal : Science, Engineering and Health Studies (SEHS) / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/electrospun-nanofibers-from-natural/
Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels (2021)
Title : Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
Researcher : Sakkarin Bhubhanil, Chanon Talodthaisong, Mattaka Khongkow, Katawut Namdee, Prapimpun Wongchitrat, Werayut Yingmema, James A. Hutchison, Sarawut Lapmanee & Sirinan Kulchat
Department : Faculty of Medicine, Siam University, Bangkok, Thailand
E-mail : sarawut.lap@siam.ed
Link to article : Scientific Reports, 2021, 11, 21836. https://doi.org/10.1038/s41598-021-01262-x
Citation : Bhubhanil, S., Talodthaisong, C., Khongkow, M.,Namdee, K., Wongchitrat, P.,Yingmema, W., Hutchison, J. A., Lapmanee S., & Kulchat, S. (2021). Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels. Scientific Reports, 11, 21836 https://doi.org/10.1038/s41598-021-01262-x
Journal : Scientific Reports / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : –
Estimation of the global burden of Mycobacterium tuberculosis lineage 1 (2021)
Title : Estimation of the global burden of Mycobacterium tuberculosis lineage 1
Researcher : Dr.Thidarat Netikul
Department : Faculty of Medicine, Siam University, Bangkok, Thailand
E-mail : med@siam.edu
Abstract : Tuberculosis is still problematic as it affects large numbers of people globally. Mycobacterium tuberculosis Lineage 1 (L1) or Indo Oceanic Lineage, one of widespread major lineages, has a specific geographic distribution and high mortality. It is highly diverse and endemic in several high burden countries. However, studies on the global burden of L1 and its sublineages remain limited. This may lead to the underestimation of the importance of its variance in developing and applying tuberculosis control measures.
This study aimed to estimate the number of patients infected with M. tuberculosis L1 and its sublineages worldwide. The proportion of L1 among tuberculosis patients was searched in published reports from countries around the world and the number of patients was calculated based on a WHO report on country incidences and populations.
The numbers of patients infected with the five major sublineages, namely L1.1.1, L1.1.2, L1.1.3, L1.2.1, and L1.2.2 were estimated where information was available. It was found that L1 accounted for 28% of global tuberculosis cases in 2012 and 2018. Over 80% of the L1 global burden was in India, the Philippines, Indonesia and Bangladesh, which are also among the countries with highest absolute numbers of tuberculosis patients in the world. Globally, the estimated number of patients infected with M. tuberculosis L1.2.1 and L1.1.2 was over 1.1 million and of patients infected with L1.1.1 was about 200,000.
This study demonstrated that L1 contributes significantly to the global burden of tuberculosis. To achieve the End TB Strategy, more attention needs to be paid to the responses of M. tuberculosis L1 to various control measures.
Keywords: Mycobacterium tuberculosis, Molecular epidemiology, East African Indian Spoligotype, Lineage 1, Sublineages of L1, Global burden
Link to Academic article: https://doi.org/10.1016/j.meegid.2021.104802
Journal : Infection, Genetics and Evolution Volume 91, July 2021, 104802
Bibliography : Thidarat Netikul, Prasit Palittapongarnpim, Yuttapong Thawornwattana, & Supada Plitphonganphim. (2021). Estimation of the global burden of Mycobacterium tuberculosis lineage 1. Infection, Genetics and Evolution, 91, 104802. https://doi.org/10.1016/j.meegid.2021.104802.
Evaluation of the integrated model of the rational drug use into the Bachelor of Nursing Science program in Thailand: A mixed-methods study (2021)
Title : Evaluation of the integrated model of the rational drug use into the Bachelor of Nursing Science program in Thailand: A mixed-methods study
Researcher : Kamolrat Turner, Kanoklekha Suwannapong, Phawida Putthikhan, Sukjai Charoensuk, Matanee Radabutr1, Naruemol Angsirisak*, Streerut Thadakant, Laddawon Vaisurasingha, & Suntharawadee Theinpichet
Department : * Faculty of Nursing, Siam University, Bangkok, Thailand
Link to article : Belitung Nursing Journal 2021, 7(6), 485-492. https://doi.org/10.33546/bnj.1762
Link to Published: Belitung Nursing Journal / Scopus
Bibliography : Kamolrat Turner, Kanoklekha Suwannapong, Phawida Putthikhan, Sukjai Charoensuk, Matanee Radabutr1, Naruemol Angsirisak, Streerut Thadakant, Laddawon Vaisurasingha, & Suntharawadee Theinpichet. (2021). Evaluation of the integrated model of the rational drug use into the Bachelor of Nursing Science program in Thailand: A mixed-methods study. Belitung Nursing Journal, 7(6), 485-492. https://doi.org/10.33546/bnj.1762
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/evaluation-of-the-integrated-model/
Evaluation of the stability and antibacterial activity of crude extracts of hydro-endophytic fungi (2021)
Title : Evaluation of the stability and antibacterial activity of crude extracts of hydro-endophytic fungi
Researcher : Surachai Techaoei1, Khemjira Jarmkom1, Thisakorn Dumrongphuttidecha1, Warachate Khobjai2
Department : 1 Department of Thai Traditional Medicine, Thai Traditional Medicine College, Rajamangala University of Technology, Pathumthani, Thailand
2 Department of Clinical Chemistry, Faculty of Medical Technology, Nation University, Lampang, Thailand
Abstract : The production and screening of secondary metabolites of four hydro-endophytes isolated from lotus, and the stability of bioactive compounds was evaluated. Surface-sterilized technique was used to isolate the endophytic fungi (EF) on potato dextrose agar and identified by using morphological and molecular techniques. The extracts were tested for anti-microbial activity against methicillin-resistant Staphylococcus aureus (MRSA) DMST20651, Streptococcus mutans (SM) DMST18777, Staphylococcus epidermidis (SE) ATCC12228, Pseudomonas aeruginosa (PA) TISTR1467, and Propionibacterium acnes (PN) DMST14916. The bacteriostatic and bactericidal activities were determined. Finally, thermal and ultraviolet (UV) stability was evaluated. Four endophyte isolates (EF 14, EF36, EF53, EF58, and EF60) produced secondary metabolites and showed activity against MRSA, SM, SE, PA, and PN, respectively. The crude ethyl acetate (EtOAc) and methanol (MeOH) extract of EF14 showed activity against MRSA with the inhibition zone of 9.00 ± 0.00 and 7.50 ± 0.50 mm, and minimum inhibitory concentration was 4.80 and 4.90 mg/mL, respectively. The minimum bactericidal concentration was 9.60 mg/mL. Whereas, the crude EtOAc and MeOH extract EF60, which were extracted by EtOAc and MeOH, showed inhibition zone of SE as 12.33 ± 0.57 and 12.33 ± 0.57 mm, respectively. Crude EtOAC extracts of EF14 showed highest thermal stability at 55°C–121°C, and UV stability with MRSA and SE, respectively. The results showed that the EtOAc extracts of EF could be potential antibacterial pathogens and displayed UV-thermal stability. This information is beneficial for future investigations, since some bioactive compounds have potential as anti-resistant strains of some bacterial pathogens.
Keywords: Antimicrobial activity, bioactive compound, hydro-endophytic fungi
Link to Academic article: DOI:10.4103/japtr.JAPTR_114_20
Journal : ,
Bibliography : Techaoei, S., Jarmkom, K., Dumrongphuttidecha, T., & Khobjai, W. (2021). Bioactivities of karanda (Carissa carandas Linn.) fruit extracts for novel cosmeceutical applications. J Adv Pharm Technol Res, 12(1), 61-66. Retrieved from
Favorable Response to Interferon-α in Infantile-onset Idiopathic Hypereosinophilic Syndrome Complicated by Status Epilepticus During Treatment (2021)
Title : Favorable Response to Interferon-α in Infantile-onset Idiopathic Hypereosinophilic Syndrome Complicated by Status Epilepticus During Treatment
Researcher : Clin.Prof.Suwat Benjaponpitak
Department : Faculty of Medicine, Siam University, Bangkok, Thailand
E-mail : med@siam.edu
Link to Academic article: DOI: 10.1097/MPH.0000000000002052
Journal : Journal of Pediatric Hematology/Oncology Published Ahead-of-Print
Bibliography : Kanchongkittiphon, W., Kittinon, K., Wanitchakorn, A., Benjaponpitak, S., & Manuyakorn, W. (2021, January 11). Favorable Response to Interferon-α in Infantile-onset Idiopathic Hypereosinophilic Syndrome Complicated by Status Epilepticus During Treatment. J Pediatr Hematol Oncol, doi: 10.1097/MPH.0000000000002052. Epub ahead of print. PMID: 33448715.