Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations (2021)
Title : Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations
Researcher : Dhakrit Rungkitwattanakul, Taniya Charoensareerat, Pathakorn Kerdnimith, Nutsinee Kosumwisaisakul, Piyakamol Teeranaew, Apinya Boonpeng, Sutthiporn Pattharachayakul, Nattachai Srisawat and Weerachai Chaijamorn
Link to article: Renal Replacement Therapy Vol. 7, Article number: 61 (2021) Page.1-11. https://doi.org/10.1186/s41100-021-00380-6
Citation : Rungkitwattanakul D., Charoensareerat T., Kerdnimith P., Kosumwisaisakul N., Teeranaew P.,Boonpeng A…Chaijamorn W. (2021). Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: Systematic review and Monte Carlo simulations. Renal Replacement Therapy, 7(61), 1-11. https://doi.org/10.1186/s41100-021-00380-6
Journal : Renal Replacement Therapy / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/imipenem-dosing-recommendations-for-patients/
Improvement of organic red pigment prodcution by Monascus Purpureus TISTR3651 using pathumthani-1 rice-based medium in submerged and solid-state fermentation (2021)
Title : Improvement of organic red pigment prodcution by Monascus Purpureus TISTR3651 using pathumthani-1 rice-based medium in submerged and solid-state fermentation
Researcher : Techaoei, S., Jarmkom, K., Dumrongphuttidacha, T., Khobjai, W.
Department :
Abstract : Objective: This research is to study the production of natural red pigment by Monascus purpureus TISTR3615 in the submerged and solid-state
fermentation system using Pathumthani-1 rice as a carbon source.
Methods: The antioxidant activity of the red pigment was evaluated in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS radical scavenging assay,
and ferric-reducing antioxidant power (FRAP) assay, including total phenolic compound.
Results and Discussion: The maximum of red pigment production was 0.55±0.02/ml (OD 680 nm) after incubation at 30°C for 24 days. The
antioxidant activity based on inhibition DPPH (%), ABTS radical scavenging activity (%), and FRAP activity (mM Fe2+/g) was 97.80±1.51,
68.64±0.46, and 0.32±0.021, respectively. The total phenolic content was 164.78±2.82 μg GAE/mg.
Conclusion: It was estimated that Monascus pigments, leading to nutraceutical and pharmaceutical applications, cosmetic industry, and food
industry.
Keywords: Natural pigment, Monascus purpureus, Submerged fermentation, Solid-state fermentation, Agricultural product
Link to Academic article: DOI: https://doi.org/10.22159/ijap.2021.v13s1.Y0103
Journal : ,
Bibliography : Techaoei, S., Jarmkom, K., Dumrongphuttidacha, T., & Khobjai, W. (Improvement of organic red pigment prodcution by Monascus Purpureus TISTR3651 using pathumthani-1 rice-based medium in submerged and solid-state fermentation. , Retrieved from https://doi.org/10.22159/ijap.2021.v13s1.Y0103
In vitro antiplatelet and anticoagulant activity of indigenous vegetables from Southern Thailand (2021)
Title : In vitro antiplatelet and anticoagulant activity of indigenous vegetables from Southern Thailand
Researcher : Sukati, S., Khobjai, W.
Department :
Abstract : Objective: Epidemiological studies have indicated that diets rich in fruits and vegetables help reduce the risk of cardiovascular diseases (CVDs). However, data about the antithrombotic activity of local vegetables is rare. The objective of this study was to evaluate antiplatelet and anticoagulant activity in indigenous vegetables with high phenolic compounds collected from Southern Thailand.
Methods: Five selected indigenous vegetables were crudely extracted by distilled water and 80% methanol. The extracts were screened for in vitro antiplatelet and anticoagulant activity at a concentration of 10 μg/μl. The antiplatelet activity was measured by inhibition of platelet adhesion to collagen and thrombin-induced platelet aggregation, while the anticoagulant activity was assessed by the prothrombin time (PT) and activated partial thromboplastin time (APTT) tests.
Results: Among the selected vegetables, the extracts of mon-pu (Glochidion perakense Hook.f.) and young cashew leaves (Anacardium occidentale L.) showed high antithrombotic properties. The highest antithrombotic activity was observed in the methanolic extract of mon-pu, which showed
92.79±0.78% of platelet adhesion inhibition, 102.9±1.53% of platelet aggregation inhibition, and a prolonged APTT assay (48.92±0.94 s). The prolonged APTT but normal PT results suggested that the extract could affect factors VIII, IX, XI, and XII of the intrinsic coagulation pathway.
Conclusion: Our findings demonstrated antiplatelet and anticoagulation properties of indigenous vegetables from Southern Thailand. The multipotential effects of mon-pu extracts on antithrombosis evidently suggest that mon-pu can be considered as an excellent nutraceutical option in the prevention of thrombosis-related CVDs caused by different mechanisms.
Keywords: Indigenous vegetables, Antiplatelet activity, Anticoagulant activity, Southern Thailand
Link to Academic article: DOI: https://doi.org/10.22159/ijap.2021.v13s1.Y0100
Journal : ,
Bibliography : Sukati, S., & Khobjai, W. (2021). In vitro antiplatelet and anticoagulant activity of indigenous vegetables from Southern Thailand. , Retrieved from https://doi.org/10.22159/ijap.2021.v13s1.Y0100
Late onset of serious agomelatine-induced liver injury (2021)
Title : Late onset of serious agomelatine-induced liver injury
Researcher : Maytinee Srifuengfung, Somporn Srifuengfung, Chalermsri Pummangura
Link to article: Sleep Medicine Vol.2021 No.86 p. 122. https://doi.org/10.1016/j.sleep.2021.06.031
Journal : Sleep Medicine / in Scopus
Citation : Srifuengfung M., Srifuengfung S. & Pummangura C. (2021). Late onset of serious agomelatine-induced liver injury. Sleep Medicine, 2021(86), 122. https://doi.org/10.1016/j.sleep.2021.06.031
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/late-onset-of-serious/
Levetiracetam dosing in patients receiving continuous renal replacement therapy (2021)
Title : Levetiracetam dosing in patients receiving continuous renal replacement therapy
Researcher : Weerachai Chaijamorn, Taniya Charoensareerat, Dhakrit Rungkitwattanakul, Sathian Phunpon, Thanompong Sathienluckana, Nattachai Srisawat & Sutthiporn Pattharachayakul
Link to article: Epilepsia Volume 62, Issue9, September 2021, Pages 2151-2158. https://doi.org/10.1111/epi.16971
Citation : Chaijamorn W., Charoensareerat T., Rungkitwattanakul D., Phunpon S., Sathienluckana T., Srisawat N. & Pattharachayakul S. (2021). Levetiracetam dosing in patients receiving continuous renal replacement therapy. Epilepsia, 62(9), 2151-2158. https://doi.org/10.1111/epi.16971
Journal : Epilepsia / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/levetiracetam-dosing-in-patients/
On The Fractional Domain Analysis of HP TiO2 Memristor Based Circuits with Fractional Conformable Derivative (2021)
Title : On The Fractional Domain Analysis of HP TiO2 Memristor Based Circuits with Fractional Conformable Derivative
Researcher : Banchuin, R.
Department : Faculty of Engineering, & Graduated School of IT, Siam University, Bangkok, Thailand
Email : rawid.ban@siam.edu
Abstract : For the first time, the physical memristor-based circuits i.e., HP TiO2 memristor-based circuits, of both series and parallel structures, have been extensively analyzed in the fractional domain by means of the state of the art yet simple fractional conformable derivative-based differential equations. Different outcome from the hypotheticalmemory element-based previous researches have been obtained. The dimensional consistencies of the fractional derivatives have also been concerned. The often-cited Joglekar’s window function has been adopted for modelling the boundary effect of the memristor and adding more nonlinearity close to the bounds of the memristor’s state variable. The formulated fractional differential equations have been solved and the related electrical quantities have been determined. The computational simulations have been performed. The stability analyses of both circuits have also been presented where it has been mathematically verified that only these HP TiO2 memristor-based circuits are stable always due to the boundary effect which does not exist in hypothetical elements assumed in those previous works. We also point out that that only those HP TiO2 memristor-based circuits of order higher than 3 are capable to exhibit the complex dynamics as such memristor lacks the local activity.
Link to article : Cogent Engineering, 2021, 8(1), 1986198. https://doi.org/10.1080/23311916.2021.1986198
Journal : Cogent Engineering / in Scopus
Citation : Banchuin, R. (2021). On the fractional domain analysis of HP TiO2 memristor based circuits with fractional conformable derivative. Cogent Engineering, 8(1), 1986198. https://doi.org/10.1080/23311916.2021.1986198
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/on-the-fractional-domain/
Phytochemical composition and antiinflammatory activity of nelumbo nucifera gaertn (2021)
Title : Phytochemical composition and antiinflammatory activity of nelumbo nucifera gaertn
Researcher : Khobjai, W., Wisidsri, N., Jarmkom, K., Techaoei, S.
Department :
Abstract : Objective: Inflammation is a process of injuries caused by physical, chemical, and biological factors. Nitric oxide (NO) plays an important role in the regulation of various pathological and pathophysiological processes. Overproduction of NO induces tissue damage associated with acute and chronic inflammations. This study was conducted to determine the phytochemical composition and the NO inhibitory properties of Nelumbo nucifera extracts
in lipopolysaccharide(LPS)-stimulated macrophage cell line.
Methods: The dried leaf, stalk, and flower materials of roseum plenum and album plenum (AP) were extracted with 95% ethanol solvents. The phytochemical compounds of the extraction were analysed by gas chromatography-mass spectrometry. The cytotoxic assay of extracts against
macrophage cells was conducted using resazurin. The NO was determined using LPS-induced RAW264.7 cells to measure inhibitory activity of extract on the production of NO.
Results: The extracts from Lotus, which exhibited the non-cytotoxic to the RAW264.7 cells. The AP-stalk extracts were capable to reduce the NO level in LPS-activated RAW264.7 cells. GC-MS analysis of AP-stalk extraction revealed pharmacologically active compounds.
Conclusion: The results conduct that the AP-stalk extract effectively inhibited the NO production and may be useful in preventing inflammatory diseases mediated by excessive production of NO. Bio-active phytoconstituents from AP stalk extract could potentially be used for anti-inflammation.
These data also suggest that AP-stalk extract may serve as a good indicator of the pharmacological activities of medicinal plants.
Keywords: Nelumbo nucifera Gaertn, Nitric oxide, RAW2647 macrophage cell, Cytotoxicity
Link to Academic article: DOI: https://doi.org/10.22159/ijap.2021.v13s1.Y0102
Journal : ,
Bibliography : Khobjai, W., Wisidsri, N., Jarmkom, K., & Techaoei, S. (2021). Phytochemical composition and antiinflammatory activity of nelumbo nucifera gaertn. , Retrieved from https://doi.org/10.22159/ijap.2021.v13s1.Y0102
Phytonutrient screening by gas chromatography–mass spectrometry and anti-aging properties of glycosmis pentaphylla (Retz.) dc. (som-chuen) extracts (2021)
Title : Phytonutrient screening by gas chromatography–mass spectrometry and anti-aging properties of glycosmis pentaphylla (Retz.) dc. (som-chuen) extracts
Researcher : Dumrongphuttidecha, T., Khobjai, W., Techaeoi, S., Jarmkom, K., Thungmungmee, S.
Department :
Abstract : Objective: The aims of this study were to screen the phytonutrient constituents and investigate their anti-aging property of leaves and bark of
Glycosmis pentaphylla (Retz.) DC. (GP).
Methods: GP is the medicinal plant which used as traditional medicine. Glycosmis pentaphylla leaves (GPL) and Glycosmis pentaphylla bark (GPB) of
GP were extracted with ethanol. The gas chromatography–mass spectrometry was used for phytonutrients analysis. The anti-aging properties were
performed using ABTS assay, deoxyribose degradation assay, bovine serum albumin (BSA)-fructose model, and matrix metalloproteinase 1 (MMP-1)
inhibitory activity.
Results: The important phytonutrients of GPL were α-tocopherol, linolenic acid, squalene, stigmasterol, and β-amyrin and for GPB were α-tocopherol,
phytol, campesterol, stigmasterol, dictamine, and γ-sitosterol. The percentage inhibition of GPL and GPB extracts at various concentrations was
between 16.57–76.05 and 20.66-78.81 by ABTS assay, 68.24–90.06 and 73.83–96.64% by deoxyribose degradation assay, 4.24–99.98 and 54.81–
99.94 by BSA-fructose model, and 6.31–81.55 and 1.06–74.45 by MMP-1 inhibitory activity, respectively.
Conclusion: Leaves and bark extracts of GP (Retz.) DC. are good sources of important phytonutrients and have the potential in anti-aging property.
Keywords: Glycosmis pentaphylla (Retz) DC, Anti-aging, Phytonutrients, Anti-Glycation, Matrix Mettalloproteinase-1
Link to Academic article: DOI: https://doi.org/10.22159/ijap.2021.v13s1.Y0105
Journal : this,
Bibliography : Dumrongphuttidecha, T., Khobjai, W., Techaeoi, S., Jarmkom, K., & Thungmungmee, S. (2021). Phytonutrient screening by gas chromatography–mass spectrometry and anti-aging properties of glycosmis pentaphylla (Retz.) dc. (som-chuen) extracts. this, Retrieved from https://doi.org/10.22159/ijap.2021.v13s1.Y0105
Prevalence and Antibiogram Profiles of Staphylococcus Aureus Isolates from Patients at Taksin Hospital, Bangkok, Thailand (January 2019 – May 2020) (2021)
Title : Prevalence and Antibiogram Profiles of Staphylococcus Aureus Isolates from Patients at Taksin Hospital, Bangkok, Thailand (January 2019 – May 2020)
Researcher : Piyawan Pipobwatthana , Chalermsri Pummangura, Sasitorn Jaroennon, Chanwit Tribuddharat, Huttaya Thuncharoon, Apichot So-Ngern, Vipavee Rodjun, Ruxjinda Wattanalai and Somporn Srifuengfung
Link to article: The Southeast Asian Journal of Tropical Medicine and Public Health, 2021, 52(2), pp. 230–239 https://journal.seameotropmednetwork.org/index.php/jtropmed/article/view/432
Journal : The Southeast Asian Journal of Tropical Medicine and Public Health / Scopus
Citation : ปิยวรรณ พิภพวัฒนา, เฉลิมศรี พุ่มมังกูร, ศศิธร เจริญนนท์, ชาญวิทย์ ตรีพุทธรัตน์, หัทยา ธัญจรูญ, อภิโชติ โซ่เงิน, วิภาวี รอดจันทร์, รักษ์จินดา วัฒนลัย และ สมพร ศรีเฟื่องฟุ้ง. (2564). Prevalence และแอนติบิโอแกรมประวัติของการแยกเชื้อ Staphylococcus Aureus จากผู้ป่วยที่โรงพยาบาลตากสินกรุงเทพมหานครประเทศไทย (มกราคม 2562 – พฤษภาคม 2563). วารสารเวชศาสตร์เขตร้อนและสาธารณสุขแห่งเอเชียตะวันออกเฉียงใต้, 52(2), 230-239.
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/prevalence-and-antibiogram-profiles/
Reference value of Forced Oscillation Technique for healthy preschool children (2021)
Title : Reference value of Forced Oscillation Technique for healthy preschool children
Researcher : Clin.Prof.Suwat Benjaponpitak
Department : Faculty of Medicine, Siam University, Bangkok, Thailand
E-mail : med@siam.edu
Abstract : Background: The reference values of Forced Oscillation Technique (FOT) parameters of the inspiratory and expiratory phase for preschool children have not yet been established.
Objective: To evaluate FOT measures in Thai healthy preschool children.
Methods: Preschool children, aged 3-6 years, were screened. Children who were positive for the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for asthma, positive family history of allergic diseases, recent lower respiratory tract infections, and environmental tobacco smoke were excluded. FOT parameters, including resistance (Rrs), reactance (Xrs), frequency of resonance (Fres) and area of reactance (ALX), were measured.
Results: A total of 390 healthy children with the mean age of 5.1 ± 0.9 years were enrolled. FOT was successfully performed in 378 children (96.9%). The mean (SD) for the whole breath (WB) resistance at 5Hz (R5), 20 Hz (R20) and R5-20 were 11.49 (2.69) cmH2O/L/s, 9.46 (2.19) cmH2O/L/s and 2.02 (0.82) cmH2O/L/s, respectively. The median (IQR) for WB reactance at 5Hx (X5), Fres and ALX were -1.51 (-2.37 to -0.96) cmH2O/L/s, 11.17 (8.50-15.65) Hz, and 7.53 (3.72-14.32) cmH2O/L/s, respectively. Significantly difference in WB R5, R20, X5, Fres and ALX between male and female children were demonstrated. The expiratory phase R5, R20, R5-20 were significantly higher than those of the inspiratory phase (p < 0.001). There are significant correlations between the height and FOT parameters. Reference curve for the FOT parameters was generated based on height using the lambda-mu-sigma (LMS) method.
Conclusion: Reference curve of FOT parameters measured in healthy preschool children were demonstrated. Majority of preschool children could perform FOT method.
Key words: Respiratory resistance, Respiratory reactance, LMS method, Frequency of resonance, Area of reactance
Link to article : Asian Pacific Journal of Allergy and Immunology, 2021, 39(2), pp. 89–95. DOI: 10.12932/AP-110618-0334
Journal : Asian Pacific journal of allergy and immunology / in Scopus
Bibliography : Mukdjindapa, P., Manuyakorn, W., Kiewngam, P., Sasisakulporn, C., Pongchaikul, P., Kamchaisatian, W., & Benjaponpitak, S. (2021). Reference value of Forced Oscillation Technique for healthy preschool children. Asian Pac J Allergy Immunol, 39(2), 89–95. doi: 10.12932/AP-110618-0334. Epub ahead of print. PMID: 30525741.