Aldosterone nongenomically induces angiotensin II receptor dimerization in rat kidney: Role of mineralocorticoid receptor and NADPH oxidase (2019)
Title : Aldosterone nongenomically induces angiotensin II receptor dimerization in rat kidney: Role of mineralocorticoid receptor and NADPH oxidase
Researcher : Sinphitukkul, K., Manotham, K., Eiam-Ong, S., Eiam-Ong, S.
Abstract :
Introduction: Previous in vitro studies demonstrated that aldosterone nongenomically induces transglutaminase (TG) and reactive oxygen species (ROS), which enhanced angiotensin II receptor (ATR) dimerization. There are no in vivo data in the kidney.
Material and methods: Male Wistar rats were intraperitoneally injected with normal saline solution, or aldosterone (Aldo: 150 μg/kg BW); or received pretreatment with eplerenone (mineralocorticoid receptor (MR) blocker, Ep. + Aldo), or with apocynin (nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, Apo. + Aldo) 30 min before aldosterone. Thirty minutes after aldosterone injection, protein abundances of dimeric and monomeric forms of AT1R and AT2R, and protein abundances and localizations of TG2 and p47phox, a cytosolic subunit of NADPH oxidase, were determined by Western blot analysis and immunohistochemistry, respectively.
Results: Protein abundances of dimeric forms of AT1R and AT2R were enhanced by 170% and 70%, respectively. Apocynin could block dimeric forms of both receptors while eplerenone inhibited only AT2R. Monomeric protein levels of both receptors were maintained. Aldosterone significantly enhanced TG2 and p47phox protein abundances, which were blunted by eplerenone or apocynin. Aldosterone stimulated p47phox protein expression in both the cortex and the medulla while TG2 was induced mostly in the medulla. Eplerenone or apocynin normalized the immunoreactivity of both TG2 and p47phox.
Conclusions: This is the first in vivo study demonstrating that aldosterone nongenomically increases renal TG2 and p47phox protein expression and then activates AT1R and AT2R dimerizations. Aldosterone-stimulated AT1R and AT2R dimerizations are mediated through activation of NADPH oxidase. Aldosterone-induced AT1R dimer formation is an MR-independent pathway, whereas the formation of AT2R dimer is modulated in an MR-dependent manner.
Keywords: NADPH oxidase; aldosterone; angiotensin II receptor dimerization; mineralocorticoid receptor; nongenomic action; rat kidney.
Link to Academic article: DOI: 10.5114/aoms.2019.87135
Journal : ,
Bibliography : Sinphitukkul, K., Manotham, K., Eiam-Ong, S., & Eiam-Ong, S. (2018). Aldosterone nongenomically induces angiotensin II receptor dimerization in rat kidney: role of mineralocorticoid receptor and NADPH oxidase.
An Analysis of the Relationship of Social Application Usage on Academic Achievement of Nursing Students, Siam University (2016)
Title : An Analysis of the Relationship of Social Application Usage on Academic Achievement of Nursing Students, Siam University
Researcher : Assist. Prof. Dr. Jaratdao Reynolds, Assist. Prof. Dr. Orntipa Songsiri and Assist. Prof. Dr. Somrudee Chenkitiyanon
Department : Faculty of Nursing, Siam University, Bangkok, Thailand
E-mail : jaratdao@gmail.com
Abstract : As we enter the 21st century, social application/networking is being used by an increasing portion of world’s population, especially adolescents and young adult on a day- to-day regular activities. Students are increasingly uses these social application /networks for both academic and non-academic reasons. However, the use of this social application has led to debate over whether or not it has impacted on students’ life as well as their academic achievement. Some studies identified that social application/networking may be the tool used in helping to develop and enhance students’ skill required for 21st century (Tuan and tu,2013). Therefore, this study was aimed to explore the relationship of social application usage among nursing students on their academic performance (GPAs). It took into account on how students participated on socialn application, time invested by students on social application, frequency of usage and the purposes of usage. The study was a cross-sectional survey, using the developed questionnaire. The data was collected from 272 students in the second and fourth year of nursing program, Siam University during the academic year 2014-2015. The data were statistically analyzed by calculating percentage, mean, standard deviation, and Pearson correlation analysis. Results indicated that all of the nursing students were using at least one form of social application. For the use of social applications, it was obviously that, Facebook and Line were the most popular social application students used (100%), followed by google (89.7%) and instragram (57.57%).Results of frequency of usage indicated that 98.16 percent of students visited a social application/networking several times a day. In term of the purposed for using the social applications, they were varied. Even though students generally use social application for academic purposes; they also use it for nonacademic matters .For non academic purposed, the results shown that 94.12 percent of students reported used the social applications for communication with friends and family, and 72.80 percent reported they used for entertainment when they felt bored. Additional reasons reported included companionship (47.06%), and making friends (27.21%). For academic purposed, searching for information was the most reason students used (77.95%), followed by learning and sharing resources (66.91%), exchange ideas and discussion (48.16%) and professional networking (36.03%) respectively. The finding of this study found negative correlations between time spent on social application usage with students’ GPAs. In other words, GPAs decreased as the amount of time spent on social application usage. The purposes of usage was also shown to be significantly correlated with students’ GPAs. The students who use social application for academic purposes seem to earned better GPAs.Therefore, in the light of globalization and the information age, integration of these social application in students’ life is unavoidable,however findingmiddle ground has become a challenge.
Proceeding : การประชุมวิชาการระดับชาติ สมาคมสถาบันอุดมศึกษาเอกชนแห่งประเทศไทย ประจำปี 2559 วันที่ 26 พฤษภาคม 2559 มหาวิทยาลัยภาคตะวันออกเฉียงเหนือ APHEIT Conference 2016
Link to Proceeding: http://apheitconference.siam.edu/index.php/en/proceedings-2012-2016
Bibliography : Jaratdao Reynolds, Orntipa Songsiri & Somrudee Chenkitiyanon. (2016). An analysis of the relationship of social application usage on academic achievement of nursing students, Siam University. In Proceedings of Conference 2016 (pp. 170-171). Khon Kaen: North Eastern University.
Analytical model of inverse memelement with fractional order kinetic (2022)
Title : Analytical model of inverse memelement with fractional order kinetic
Researcher : Banchuin, R.
Department : Faculty of Engineering & Graduated School of IT, Siam University, Bangkok, Thailand
Email : rawid.ban@siam.edu
Abstract : In this work, the analytical model of inverse memelement with fractional order kinetic has been proposed. The classical yet noncontroversial Caputo fractional derivative has been adopted for modeling such fractional order kinetic due to its simplicity yet accuracy. Based on the proposed model, the analysis of fractional order kinetic inverse memristor has been thoroughly performed where both nonperiodic and periodic excitations have been considered. Analytical formulations of the related parameters, for example, the rate of changes of inverse memristance, area of inverse memristance loop, and area of pinched hysteresis loop, and so on, have been performed. The extension of the proposed model to the fractional inverse memelement has been performed where the fractional inverse memristor has been analyzed. We have found that the inverse memristor still behaves in an opposite manner to the memristor even with the fractional order kinetic. All obtained results have been found to be intuitively applicable to any inverse memelement. The equivalent circuit models of both fractional inverse memristor and fractional inverse memelement have also been presented. This work provides a comprehensive understanding on both inverse memelement with fractional order kinetic and fractional inverse memelement. The realization of the emulator of such inverse memelement with fractional order kinetic and the fractional inverse memelement emulator has been found to be interesting opened research questions.
Link to article : International Journal of Circuit Theory and Applications, 2022, 50(7), pp. 2342–2377. https://doi.org/10.1002/cta.3264
Journal : International Journal of Circuit Theory and Applications / in Scopus
Bibliography : Banchuin, R. (2022). Analytical model of inverse memelement with fractional order kinetic. International Journal of Circuit Theory and applications, 50(7), 2342-2377. https://doi.org/10.1002/cta.3264
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/analytical-model-of-inverse/
Anatomical and Ultrasonography-Based Investigation to Localize the Arteries on the Central Forehead Region During the Glabellar Augmentation Procedure (2020)
Title : Anatomical and Ultrasonography-Based Investigation to Localize the Arteries on the Central Forehead Region During the Glabellar Augmentation Procedure
Researcher : Phumyoo, T., Jiirasutat, N., Jitaree, B., Rungsawang, C., Uruwan, S., Tansatit, T.
Abstract : Glabellar augmentation is one of the most popular cosmetic procedures but can entail severe complications caused by inadvertent intravascular injection of filler. Nevertheless, few studies have investigated the arteries on the glabellar and central forehead regions. The aim of this study was to correlate the topography and location of the arteries in this area with anatomical landmarks to propose a safety guideline. Two methods were used to investigate the glabellar and central forehead areas: dissection of 19 Thai embalmed cadavers, and ultrasonographic examination of 14 healthy Thai volunteers. At the level of the glabellar point, the horizontal distances from the midline to the arteries were 4.7 mm (central artery), 7.8 mm (paracentral artery), and 14.7 and 19.2 mm (superficial and deep branches of supratrochlear artery). The depths from the skin of the arteries were 3.1 mm (central artery), 4.8 mm (paracentral artery), and 4.2 and 5.9 mm (superficial and deep branches of supratrochlear artery). The periosteal artery was detected in 71.1% as a branch of either the superior orbitoglabellar or the supratrochlear artery. It ran in the supraperiosteal layer for a short course and penetrated the periosteum above the superciliary ridge or above the medial eyebrow, adhering tightly to the bony surface. This study suggests a safe injection technique for the glabella based on a thorough knowledge of arterial distribution and topography and color Doppler ultrasonographic examination prior to the injection, which is recommended to minimize the risk of severe complications. Clin. Anat. 33:370–382, 2020. © 2019 Wiley Periodicals, Inc.
Link to Academic article: https://doi.org/10.1002/ca.23516
Journal : ,
Bibliography : Phumyoo, T., Jiirasutat, N., Jitaree, B., Rungsawang, C., Uruwan, S., & Tansatit, T.(2020). Anatomical and Ultrasonography-Based Investigation to Localize the Arteries on the Central Forehead Region During the Glabellar Augmentation Procedure. ,
Anatomical knowledge of zygomatico-buccal plexus in a cadaveric study (2023)
Title : Anatomical knowledge of zygomatico-buccal plexus in a cadaveric study
Researcher : Uruwan, S., Rungsawang, C.Sareebot, T., Tansatit, T.
Abstract : The details of the facial nerve pattern were clearly explained in the parotid gland (PG), lateral area of the face, and periorbital areas to prevent the unexpected outcome of medical intervention. However, it remains unclear whether information about the zygomatico-buccal plexus (ZBP) in the masseteric and buccal regions. Therefore, this study aimed to help clinicians avoid this ZBP injury by predicting their common location. This study was conducted in forty-two hemifaces of twenty-nine embalmed cadavers by conventional dissection. The characteristics of the buccal branch (BB) and the ZBP were investigated in the mid-face region. The results presented that the BB gave 2-5 branches to emerge from the PG. According to the masseteric and buccal regions, the BB were arranged into ZBP in three patterns including an incomplete loop (11.9%), a single-loop (31.0%), and a multi-loop (57.1%). The mean distance and diameter of the medial line of the ZBP at the corner of the mouth level were 31.6 (6.7) and 1.5 (0.6) mm respectively, while at the alar base level were 22.5 (4.3) and 1.1 (0.6) mm respectively. Moreover, the angular nerve arose from the superior portion of the ZBP at the alar base level. The BB formed a multiloop mostly and showed a constant medial line of ZBP in an area approximately 30 mm lateral to the corner of the mouth, and 20 mm lateral to the alar base. Therefore, it is recommended that physicians should be very careful when performing facial rejuvenation in the mid-face region.
Keywords: Buccal branch; Facial rejuvenation; Zygomatico-buccal plexus.
Link to article : Anatomy and Cell Biology, 2023, 56(3), pp. 313–321. https://doi.org/10.5115/acb.23.040
Journal : Anatomy and Cell Biology / in Scopus
Citation : Uruwan, S., Rungsawang, C., Sareebot, T., & Tansatit, T. (2023). Anatomical knowledge of zygomatico-buccal plexus in a cadaveric study. Anatomy and Cell Biology, 56(3), 313–321. https://doi.org/10.5115/acb.23.040
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : –
Anatomical Study of the Dorsal Nasal Artery to Prevent Visual Complications during Dorsal Nasal Augmentation (2021)
Title : Anatomical Study of the Dorsal Nasal Artery to Prevent Visual Complications during Dorsal Nasal Augmentation
Researcher : Tansatit, T., Jitaree, B.,Uruwan, S. Rungsawang, C.,
Abstract : Dorsal nasal augmentation is a common injection associated with ocular complications. Digital compressions on both sides of the nose are recommended during injection. Considering the reported incidences of visual complications, this preventive technique may need an adjustment for more effectiveness to prevent blindness. Therefore, the dorsal nasal arteries (DNAs) were studied by conventional dissections in the subcutaneous and fibromuscular tissues of the nasal dorsum in 60 embalmed cadavers. The results showed that among the 60 faces, 32 faces had bilateral DNAs (53.3%), 23 had dorsal nasal plexus with minute arteries (38.3%), and five had a single dominant DNA (8.3%). The DNA originated from one of the four arterial sources, which influenced the location and course of the artery. These sources included the ophthalmic angular arteries in 21 faces (56.8%), terminal ophthalmic arteries in two faces (5.4%), lateral nasal arteries in 11 faces (29.7%) and facial angular arteries in three faces (8.1%). Consequently, the dominant dorsal nasal artery running close to the midline found in 8% of the cases could make side compressions during nasal dorsum augmentation less effective from preventing ocular complications. However, an adjustment of digital compressions which combines pinching and side compressions is suggested to improve the safety.
Link to article: , 2021, 9(11), pp. E3924. https://doi.org/10.1097/GOX.0000000000003924
Citation : Tansatit, T., Jitaree, B., Uruwan, S. & Rungsawang, C., (2021). Anatomical Study of the Dorsal Nasal Artery to Prevent Visual Complications during Dorsal Nasal Augmentation. , 9(11), e3924. https://doi.org/10.1097/GOX.0000000000003924
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : –
Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts (2020)
Title : Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts
Researcher : Monsicha Khuanekkaphan1, Chanai Noysang2, Warachate Khobjai3
Department : 1 Department of Health and Aesthetics, Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand
2 Department of Innovation of Health Products, Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand
3 Department of Applied Thai Traditional Medicine, Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand
Abstract : Centella asiatica, Nelumbo nucifera Gaertn, and Hibiscus sabdariffa have been used as medicinal plants in Thailand. They are sources of phytochemicals that applications for esthetic and healthcare. The aim of this research was to examine the phytochemical constituents and anti-aging potential of these plants. The phytochemical compounds were performed using gas chromatography-mass spectrometry. The anti-aging activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis (3-ethylbenzothiazoline-6-sunfonic acid) (ABTS), anti-collagenase, and anti-elastase assays. The main interest phytochemical compounds of ethanolic extracts of C. asiatica, N. nucifera, H. sabdariffa were ethanol, 2-(-Octadecenyloxy), γ-sitosterol and hexadecanoic acid, and ethyl ester, respectively. The DPPH half-maximal inhibitory concentration (IC50) results of C. asiatica, N. nucifera, and H. sabdariffa were 0.32 ± 0.01, 0.34 ± 0.00, and 0.35 ± 0.01 mg/mL, respectively. The ABTS result of H. sabdariffa extract showed high inhibitory activity at IC50of the extract was 0.62 ± 0.12 mg/mL. The percentage of collagenase inhibition of C. asiatica, N. nucifera, and H. sabdariffa at 1.0 mg/mL was 78.13 ± 4.42, 85.94 ± 2.21, and 90.63 ± 0.00, respectively. The C. asiatica extract had a high percentage of elastase inhibition. Consequently, these research results suggest that phytochemicals may also provide a range of esthetic and health benefits. The phytochemical constituent could be used as anti-aging active ingredient for cosmetic and pharmaceutical industrials.
Keywords: Anti-aging, Centella asiatica, Hibiscus sabdariffa, Nelumbo nucifera, phytochemical
Link to Academic article: DOI: 10.4103/japtr.JAPTR_79_20
Journal : this link is disabled,
Bibliography : Khuanekkaphan, M., Noysang, C., & Khobjai W. (2020). Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts. J Adv Pharm Technol Res, 11(4), 174-178. Retrieved from https://www.japtr.org/text.asp?2020/11/4/174/297699
Antimicrobial Dosing Concepts in Patients with Reduced Kidney Function (2560)
Antimicrobial Dosing Concepts in Patients with Reduced Kidney Function (2560)
ผู้เขียนบทความ: ผู้ช่วยศาสตราจารย์ ดร. ภก. วีรชัย ไชยจามร
บทคัดย่อ:
การใช้ยาต้านจุลชีพสำหรับการรักษาภาวะติดเชื้อ จำเป็นต้องพิจารณาจากปัจจัยหลายด้าน ทั้งจากยาต้านจุลชีพและสภาวะผู้ป่วย เชื้อก่อโรค รวมถึงบริเวณที่ติดเชื้อ ในอดีต ปัจจัยสำคัญที่เป็นตัวกำหนดในการเลือกยาต้านจุลชีพได้แก่ เชื้อก่อโรค ค่า minimum inhibitory concentration (MIC) และความไวของเชื้อ (in vitro antimicrobial susceptibility patterns) แต่การพิจารณาจากปัจจัยดังกล่าวข้างต้นยังไม่เพียงพอในการดูแลผู้ป่วยภาวะติดเชื้อให้เหมาะสมและมีประสิทธิภาพ ปัจจัยอื่นที่ต้องพิจารณาร่วมด้วยคือ การมีระดับยาที่เพียงพอในบริเวณที่เกิดภาวะติดเชื้อ (infection site) และพยาธิสภาพของผู้ป่วยที่ส่งผลต่อเภสัชจลนศาสตร์และเภสัชพลศาสตร์ของยาต้านจุลชีพที่เลือกใช้ เพื่อให้เกิดผลลัพธ์ในการรักษาที่ดี คือ การหายจากภาวะติดเชื้อ การป้องกันการเกิดเชื้อดื้อยา และผู้ป่วยไม่เกิดพิษจากการได้รับยาต้านจุลชีพในขนาดที่ไม่เหมาะสม
คำสำคัญ:
Link to Academic article: Antimicrobial Dosing Concepts in Patients with Reduced Kidney Function
Applying a mixed method of quantitative and qualitative design in explaining the travel motivation of film tourists in visiting a film-shooting destination (2015)
Title : Applying a mixed method of quantitative and qualitative design in explaining the travel motivation of film tourists in visiting a film-shooting destination
Researcher : Bongkosh Rittichainuwat and Suphaporn Rattanaphinanchai
Department : Service Industry Management, Siam University, Bangkok, Thailand
E-mail : Bongkosh N. Rittichainuwat ngamson@gmail.com
Abstract : This study aims to: 1) describe the travel motivations of the types of film tourists proposed by Macionis (2004), specifically, serendipitous tourists, specific film tourists, and general film tourists, in visiting a film-induced tourist destination; and 2) empirically test the assumption that film tourism is incidental and neither the main nor the sole motivation of most tourists traveling to a film destination. A mixed method of quantitative and qualitative (a series of self-complete questionnaire surveys over a period of eleven months and a longitudinal study of interviews and participant observations over a period of four years) was used in the study. Out of 1852 samples, the numbers of specific film tourists (10.5%) and general film tourists (19.5%) are less than serendipitous tourists (70%). Though both business and leisure tourists can be specific film tourists, their number is very small. Furthermore, serendipitous tourists can be distributed into almost equal numbers, namely, “incidental serendipitous tourists,” “disinterested serendipitous tourists,” and “sightseeing serendipitous tourists.” While successful films create destination awareness among all types of film tourists, an individual’s favorite film, rather than a successful film, motivated most specific film tourists to take a pilgrimage film trip. This study also highlights the value of the mixed method, of a quantitative and qualitative approach, in explaining film tourism, in regards to unusual behavior of outliers. Whereas the quantitative design increases the generalization of the findings, the qualitative method provides better understanding of contradictory findings without having to eliminate outliers from analysis.
Publication : Tourism Management Vol.46 February 2015
Link to Publication: https://www.sciencedirect.com/journal/tourism-management/vol/46/suppl/C
Bibliography : Rittichainuwat, B. & Rattanaphinanchai, S. (2015). Applying a mixed method of quantitative and qualitative design in explaining the travel motivation of film tourists in visiting a film-shooting destination. Tourism Management, 46, 136-147. 10.1016/j.tourman.2014.06.005
Author details in Scopus: Rittichainuwat, Bongkosh Ngamsom
Scopus Citations: https://www.scopus.com/sources.uri?DGCID=Scopus_blog_post_check2015
Google Scholar Citations: https://scholar.google.com/citations?user=ifUlKJoAAAAJ&hl=en
Applying Correlation Analysis and Tam for Determining Relationship Between Two Variables
Title : Applying Correlation Analysis and Tam for Determining Relationship Between Two Variables
Researcher : Pitchayakorn Lake พิชญากร เลค
Department : Faculty of Information Technology, Siam University, Bangkok, Thailand
E-mail : pitchayakorn@siam.edu
Abstract : Future scenarios of political, economics and education sectors will depend on the contributions of students. The twenty-first century educator is a visionary. Teachers see the potential in the emerging tools and technology innovations in order to manipulate them to serve student’s needs. The universities across the world have incorporated in learning systems. The success of educator requires an extensive understanding of technology innovations. Educational innovations will be effective if they research on educational technology i.e. technology-learning process and technology in using hardware and software. The research use TAM in order to stimulate to learn more.
The objective of this research is to study the relationship between two variables of Information Technology and Computer for Studies and Works by using correlation analysis. Data collection were obtained from 284 respondents with the mean of 406.6 on MS. Word and SD. is 291.9. The mean on MS. Excel is 291.9 and SD. is 313.8. The students who got MS. Word scores better on average than MS. Excel scores. Out of the 284 respondents 128 (45.1%) were male and 156 (54.9%) were female. The result shows that correlations coefficient is 0.749. The coefficient is calculated by taking the covariance of the two variable. The students who got MS. Word and MS. Excel scores, were linear correlated statistically significant at 0.05 (F=360.63, p = 0.000). The researcher used variable of MS. Word scores as a predictor, which can predict 56.1% of MS. Excel scores. The regression equation is MS. Word = 131.718 + 0.942 (MS. Excel).
Keywords : Information Technology, Computer for Studies and Works, Correlation Analysis
Proceeding : การประชุมวิชาการระดับชาติ สมาคมสถาบันอุดมศึกษาเอกชนแห่งประเทศไทย ประจำปี 2559 วันที่ 26 พฤษภาคม 2559 มหาวิทยาลัยภาคตะวันออกเฉียงเหนือ APHEIT Conference 2016
Link to Proceeding: http://apheitconference.siam.edu/index.php/en/proceedings-2012-2016
Bibliography : Pitchayakorn Lake. (2016). Applying correlation analysis and tam for determining relationship between two variables. In Proceedings of APHEIT Conference 2016 (pp. 139). Khon Kaen: North Eastern University.