Clinically significant drug interactions among HIV-infected patients receiving antiretroviral therapy (2014)
Abstract
We conducted a cross sectional study of the outpatient medical records of 1,000 HIV-infected patients receiving antiretroviral therapy (ART) in 2011 to determine the incidence of clinically significant drug interactions (CSDI). The severities of the CSDI were graded following the Micromedex® 2.0 database and the Department of Health and Human Services (DHHS) 2012 HIV treatment guidelines. Three hundred thirty-five patients (34%) had 554 episodes of CSDI. Of which 337 episodes (61%), 163 episodes (29%) and 54 episodes (10%) had grades 2, 3 and 4 severity CSDI, respectively. The CSDI were caused by protease inhibitor (PI)-based drug regimens in 79%, by efavirenz-based regimens in 34% and by nevirapine-based regimens in 10% (p<0.001). The three most common grade 4 CSDI were: a PI with simvastatin (n=24), simvastatin with gemfibrozil (n=24) and didanosine with allopurinol (n=2). The three most common grade 3 CSDI were: a PI with a statin drug except simvastatin (n=56), fenofibrate with a statin drug (n=28) and amlodipine with simvastatin (n=14). On multivariate analysis, risk factors associated with CSDI were: receiving a PI-based regimen (OR 14.44; 95%CI: 9.10-22.88), having dyslipidemia (OR 3.94; 95%CI: 1.89-8.21), having >5 items prescribed at a time (OR 1.80; 95%CI: 1.23-2.63), seeing a doctor >4 times a year (OR 1.72; 95%CI: 1.20-2.46), having hypertension (OR 0.60; 95%CI: 0.37-0.98), having a duration of receiving ART of >5 years (OR 0.46; 95%CI: 0.28-0.77) and having a CD4 count of >200 cells/mm3 (OR 0.46; 95%CI: 0.26-0.84). CSDI were common among HIV-infected patients receiving ARV in our outpatient clinic. Patients having a low CD4 count, having dyslipidemia, receiving PI-based ART, having a frequent number of visits per year and having a large number of items prescribed at each visit had a greater chance of a CSDI.
Keywords: antiretroviral, drug interaction, HIV, Thailand
Link to Publication: http://www.tm.mahidol.ac.th/seameo/journal-45-5-2014.html / in Scopus
Bibliography : So-Ngern, A., Montakantikul, P. & Manosuthi, W. (2014). Clinically significant drug interactions among HIV-infected patients receiving antiretroviral therapy. Southeast Asian J Trop Med Public Health, 45(5), 1023-1031.
Commentary on: Deployment of the Ophthalmic and Facial Angiosomes in the Upper Nose Overlaying the Nasal Bones (2021)
Title : Commentary on: Deployment of the Ophthalmic and Facial Angiosomes in the Upper Nose Overlaying the Nasal Bones
Researcher : Tansatit, T., Phumyoo, T., Jitaree, B., Rungsawang, C., Uruwan, S.
Abstract : The authors studied patterns of nasal angiosomes focusing on the arterial sources of the upper nose and the midline anastomoses employing 3-dimensional reconstructed computed tomography imaging with radiopaque enhancement in 62 fresh cadaver heads.1 Unfortunately, the presence of subcutaneous plexuses interfered with visualization of the deep arteries. After some technical adjustment, only 26 cadaver noses were available for analysis. The authors carefully classified nasal arterial patterns into 3 types with additional 7 subtypes. Besides their fantastic work, the authors transferred their findings into clinical practice and estimated blindness risks. Some additional issues of blindness risks are further discussed in this comment for more clarification.
Link to Academic article: https://doi.org/10.1093/asj/sjaa397
Journal : ,
Bibliography : Tansatit, T., Phumyoo, T., Jitaree, B., Rungsawang, C., & Uruwan, S. (2021). Commentary on: Deployment of the Ophthalmic and Facial Angiosomes in the Upper Nose Overlaying the Nasal Bones. ,
Commentary on: Safe Glabellar Wrinkle Correction with Soft Tissue Filler Using Doppler Ultrasound (2021)
Title : Commentary on: Safe Glabellar Wrinkle Correction with Soft Tissue Filler Using Doppler Ultrasound
Researcher : Phumyoo, T., Tansatit, T., Jitaree, B.
Abstract : The authors suggest that Doppler ultrasound can be used to locate the supratrochlear artery before hyaluronic acid filler injection at the glabellar wrinkles to avoid ophthalmologic complications.1 In 42 patients with 74 glabellar wrinkle lines, they reported that the supratrochlear arteries were located both at the glabellar wrinkle lines (30/74, 41%) and lateral to the glabellar wrinkle lines (44/74, 59%). They abandoned filler injection in patients whose supratrochlear artery was located at the glabellar wrinkle lines. In these 30 potentially at-risk glabellar lines, the artery was located at the deep subcutaneous layer in 24 and at the subdermal layer in 6 wrinkle lines.
Link to Academic article: https://doi.org/10.1093/asj/sjaa326
Journal : ,
Bibliography : Phumyoo, T., Tansatit, T., & Jitaree, B. (2021). Commentary on: Safe Glabellar Wrinkle Correction with Soft Tissue Filler Using Doppler Ultrasound. ,
Comparative analyses of electrical circuits with conventional and revisited definitions of circuit elements: a fractional conformable calculus approach (2022)
Title : Comparative analyses of electrical circuits with conventional and revisited definitions of circuit elements: a fractional conformable calculus approach
Researcher : Banchuin, R.
Department : Faculty of Engineering, & Graduated School of IT, Siam University, Bangkok, Thailand
Email : rawid.ban@siam.edu
Abstract :
Purpose
Design/methodology/approach
Findings
Originality/value
Link to article : COMPEL – The International Journal for Computation and Mathematics in Electrical and Electronic Engineering, 2022, 41(1), pp. 258-282. https://doi.org/10.1108/COMPEL-03-2021-0079
Journal : COMPEL – The International Journal for Computation and Mathematics in Electrical and Electronic Engineering / in Scopus
Citation: Banchuin, R. (2022). Comparative analyses of electrical circuits with conventional and revisited definitions of circuit elements: A fractional conformable calculus approach. COMPEL – The International Journal for Computation and Mathematics in Electrical and Electronic Engineering, 41(1), 258-282. https://doi.org/10.1108/COMPEL-03-2021-0079
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/comparative-analyses-of-electrical-circuits/
Comparative analysis of suitability of fractional derivatives in modelling the practical capacitor (2022)
Title : Comparative analysis of suitability of fractional derivatives in modelling the practical capacitor
Researcher : Banchuin, R.
Department : Faculty of Engineering, & Graduated School of IT, Siam University, Bangkok, Thailand
Email : rawid.ban@siam.edu
Abstract :
Purpose
Design/methodology/approach
Findings
Originality/value
Link to article : COMPEL – The International Journal for Computation and Mathematics in Electrical and Electronic Engineering, 2022, 41(1), 304-318. https://doi.org/10.1108/COMPEL-08-2021-0293
Journal : COMPEL – The International Journal for Computation and Mathematics in Electrical and Electronic Engineering / in Scopus
Citation : Banchuin, R. (2022). Comparative analysis of suitability of fractional derivatives in modelling the practical capacitor. COMPEL – The International Journal for Computation and Mathematics in Electrical and Electronic Engineering, 41(1), 304-318. https://doi.org/10.1108/COMPEL-08-2021-0293
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/comparative-analysis-of-suitability/
Comparative in vitro activity of sitafloxacin against multidrug-resistant and carbapenem-resistant acinetobacter baumannii clinical isolates in Thailand (2020)
Title : Comparative in vitro activity of sitafloxacin against multidrug-resistant and carbapenem-resistant acinetobacter baumannii clinical isolates in Thailand
Researcher : Taniya Paiboonvong1,Vipavee Rodjun2,Jantana Houngsaitong1,Mullika Chomnawang3,Preecha Montakantikul2,Suvatna Chulavatnatol2*
1 Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
2 Faculty of Pharmacy, Siam University, Bangkok, Thailand
3 Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : –
Link to article: Pharmaceutical Sciences Asia, 2020, 47(1), pp. 37–42 https://pharmacy.mahidol.ac.th/journal/journalabstractDetail.php?jvol=47&jpart=1&jconnum=4
Journal :Pharmaceutical Sciences Asia/ Scopus
Citation : Paiboonvong, T., Rodjun, V., Houngsaitong, J., Chomnawang, M., Montakantikul,P., & Chulavatnatol, S. (2020). Comparative in vitro activity of sitafloxacin against multidrug-resistant and carbapenem-resistant acinetobacter baumannii clinical isolates in Thailand. Pharmaceutical Sciences Asia, 47(1), 37–42. https://doi.org/10.29090/psa.2020.01.019.0012
Comparison between Penetration Forces for a 25-Gauge Cannula to Perforate an Artery at 45-Degree and 90-Degree Angles (2022)
Title : Comparison between Penetration Forces for a 25-Gauge Cannula to Perforate an Artery at 45-Degree and 90-Degree Angles
Researcher : Tansatit, T., Uruwan, S., Rungsawang, C.
Abstract : A cannula facilitates wide injections and deviates arteries.1,2 Previous studies measured cannula penetration force regardless of angle.3,4 We measured the penetration force of a cannula at two different angles in three arterial segments.
Ten facial arteries from five soft embalmed cadavers, aged 45 to 63 years, were tested at the mandibular body, oral commissure, and lower ala. Both segmental ends were grabbed. A 25-gauge cannula attached to a force gauge pierced the arterial wall at 45 and 90 degrees. In addition, the bifurcation of the artery at the superior labial artery was tested.
Link to Academic article: DOI: 10.1097/PRS.0000000000009722
Journal :, / in Scopus
Citation : Tansatit, T., Uruwan, S., & Rungsawang, C. (2022). Comparison between Penetration Forces for a 25-Gauge Cannula to Perforate an Artery at 45-Degree and 90-Degree Angles.
Comparison of aroma active and sulfur volatiles in three fragrant rice cultivars using GC–Olfactometry and GC–PFPD (2014)
Researcher : Kanjana Mahattanatawee*, Russell L. Rouseff
Department : *Food Technology Department, Faculty of Science, Siam University
E-mail : *kanjana@siam.edu
Abstract : Aroma volatiles from three cooked fragrant rice types (Jasmine, Basmati and Jasmati) were characterised and identified using SPME GC–O, GC–PFPD and confirmed using GC–MS. A total of 26, 23, and 22 aroma active volatiles were observed in Jasmine, Basmati and Jasmati cooked rice samples. 2-Acetyl-1-pyrroline was aroma active in all three rice types, but the sulphur-based, cooked rice character impact volatile, 2-acetyl-2-thiazoline was aroma active only in Jasmine rice. Five additional sulphur volatiles were found to have aroma activity: dimethyl sulphide, 3-methyl-2-butene-1-thiol, 2-methyl-3-furanthiol, dimethyl trisulphide, and methional. Other newly-reported aroma active rice volatiles were geranyl acetate, β-damascone, β-damascenone, and ɑ-ionone, contributing nutty, sweet floral attributes to the aroma of cooked aromatic rice. The first two principal components from the principal component analysis of sulphur volatiles explained 60% of the variance. PC1 separated Basmati from the other two cultivars and PC2 completely separated Jasmine from Jasmati cultivars.
Keywords: PCA, Cooked rice, Headspace SPME
Link to Publication: Food Chemistry/ in Sopus
Bibliography : Mahattanatawee, K., & Rouseff, R. L.(2014). Comparison of aroma active and sulfur volatiles in three fragrant rice cultivars using GC–Olfactometry and GC–PFPD. Food Chemistry, 154, 1-6.
Comparison of Aroma Character Impact Volatiles of Thummong Leaves (Litsea petiolata Hook. f.), Mangdana Water Beetle (Lethocerus indicus), and a Commercial Product as Flavoring Agents in Thai Traditional Cooking (2018)
Researcher : Kanjana Mahattanatawee, Torsak Luanphaisarnnont, Russell Rouseff
Department : Food Technology Department, Faculty of Science, Siam University
E-mail : kanjana@siam.edu
Abstract : Thummong (Litsea petiolata Hook. f.) is a tree native to southern Thailand. The leaves of this tree are highly aromatic and used to flavor Thai dishes in place of the traditional water beetle Mangdana (Lethocerus indicus) for religious and cultural reasons. Total and aroma-active volatiles from both flavoring materials were compared using gas chromatography–olfactory (GC–O) and gas chromatography–mass spectrometry (GC–MS). The volatiles from Thummong leaves and the Mangdana water beetle were collected and concentrated using headspace solid-phase microextraction. A total of 23 and 25 aroma-active volatiles were identified in Thummong leaves and Mangdana, respectively. The major aroma-active volatiles in Thummong leaves consisted of 7 aldehydes, 5 ketones, and 3 esters. In contrast, the aroma-active volatiles in the water beetle consisted of 11 aldehydes, 3 esters, and 2 ketones. Both had (E)-2-nonenal as the most intense aroma-active volatile. The water beetle character impact volatile (E)-2-hexenyl acetate was absent in the leaves, but its aroma character was mimicked by 11-dodecen-2-one in the leaves, which was absent in the beetle. In addition, a commercial Mangdana flavoring was examined using GC–O and GC–MS and found to contain only a single aroma-active volatile, hexyl acetate. All three flavoring sources exhibited similar aroma characteristics but were produced from profoundly different aroma-active volatiles.
Link to Publication: Journal of Agricultural and Food Chemistry, Vol.66 Issue 10 March 2018
Bibliography : Mahattanatawee, K., Luanphaisarnnont, T., & Rouseff R. (2018). Comparison of aroma character impact volatiles of thummong leaves (litsea petiolata hook. f.), Mangdana water beetle (lethocerus indicus), and a commercial product as flavoring agents in Thai traditional cooking. Journal of Agricultural and Food Chemistry, 66(10), 2480-2484.
Comparison of Efficacy and Safety between Long-Acting Injectable Antipsychotic Monotherapy and Combination of Long-Acting Injectable and Oral Antipsychotics in Patients with Schizophrenia (2021)
Title : Comparison of Efficacy and Safety between Long-Acting Injectable Antipsychotic Monotherapy and Combination of Long-Acting Injectable and Oral Antipsychotics in Patients with Schizophrenia
Researcher : Sathienluckana, T., Tiangpattanawong, P., Chaiyasukthananoan, K., Jittayanan, P., Sawetwangsing, H., Puchsaka, P.
Abstract : Background
Long-acting injectable (LAI) antipsychotics are used as a monotherapy in patients with schizophrenia. However, the combination of LAI and oral antipsychotics is commonly used in clinical practice, despite there being very limited studies investigating the efficacy and safety of this combination compared with LAI antipsychotic monotherapy.
Objective
To study the efficacy and safety of LAI antipsychotic monotherapy compared with the combination of LAI and oral antipsychotics in patients with schizophrenia.
Methods
This study was a retrospective cohort study, which classified eligible patients into two groups: the LAI antipsychotic monotherapy group and the combination of LAI and oral antipsychotic group. The primary outcome was hospitalization between groups. The duration of the study was 2 years.
Results
In total, 86 patients completed the study and were analysed (LAI antipsychotic monotherapy group: n = 25; combination of LAI and oral antipsychotic group: n = 61). There was no significant difference in hospitalization between the two groups (P = 1.000). For other outcomes, there were also no significant differences in both all-cause discontinuation (P = 0.667) and adverse drug reactions (P = 0.732) between the two groups.
Conclusion
The efficacy and safety of LAI antipsychotic monotherapy appeared similar to the combination of LAI and oral antipsychotics in patients with schizophrenia. Therefore, the combination of LAI and oral antipsychotics, which is commonly used in clinical practice, may not be necessary.
Link to article: doi: 10.1155/2021/8403986
Journal : Schizophr Res Treatment
Bibliography : Sathienluckana, T., Tiangpattanawong, P., Chaiyasukthananoan, K., Jittayanan, P., Sawetwangsing, H., & Pummangura, C. (Comparison of Efficacy and Safety between Long-Acting Injectable Antipsychotic Monotherapy and Combination of Long-Acting Injectable and Oral Antipsychotics in Patients with Schizophrenia. this,