Nomogram of cervical length at mid-trimester in normal thai pregnant women (2018)
Title : Nomogram of cervical length at mid-trimester in normal thai pregnant women
Researcher : Kovavisarach, E., Sukontaman, W.
Abstract : Background:As cervical length decreases in the second trimester, the risk of spontaneous preterm birth increases, especially when effacement occurs early in the second trimester, and it is often detected on ultrasound examination before it can be identified by physical examination. To date, only two Thai nomograms of transvaginal cervical length have been reported.
Objective: To establish a new Thai nomogram as a reference for evaluation of transvaginal cervical length in a tertiary Thai hospital in Bangkok (Rajavithi Hospital: RH) during gestational age (GA) 16 to 24 weeks.
Material and Method: This research was approved by the ethics committee of RH (No. 055/2558). A total of 286 normal Thai pregnant women who attended the antenatal clinic (ANC) at RH between May 1, 2015 and November 30, 2015 were included. All were cases of singleton gestation with no medical or obstetric complications and no fetal congenital anomalies; and all had GA confirmed by Crown Rump Length (CRL) before GA of 14 weeks. Cervical length measurement was performed by a single operator using transvaginal ultrasonography (7.5 mHz Voluson E8) during GA of 16 to 24 weeks. The subjects attended follow-up sessions in the antenatal care clinic until delivery.
Results:One hundred and ninety-six cervical measurements were analysed (90 patients were excluded: 7 because of preterm labor, and 83 because they were lost to follow-up). The mean maternal age was 29.49+6.5 years, and the most common pregnancy status was nullipara (48.3%). The mean CL of nulliparous, multiparous and overall women were 37.87, 39.46 and 38.70 mm respectively. The CL values were constant during the examined GA.
Conclusion:The mean cervical length of normal Thai pregnant women between GA of 16 to 24 weeks examined transvaginally
was 38.70 mm.
Keywords: Cervical length (CL), Transvaginal ultrasonography
Link to Academic article: http://www.jmatonline.com/index.php/jmat/article/view/9091
Journal : ,
Bibliography : Kovavisarach, E., & Sukontaman, W. (2018). Nomogram of cervical length at mid-trimester in normal thai pregnant women.
Nongenomic action of aldosterone on colocalization of angiotensin II type 1 and type 2 receptors in rat kidney (2018)
Title : Nongenomic action of aldosterone on colocalization of angiotensin II type 1 and type 2 receptors in rat kidney
Researcher : Sinphitukkul, K., Manotham, K., Eiam-Ong, S., Eiam-Ong, S.
Abstract : Previous in vitro studies have demonstrated that angiotensin II type 1 and type 2 receptors (AT1R and AT2R) are co-localized and can form AT1R/AT2R dimerization in rat proximal tubular cells. Aldosterone non-genomically enhances angiotensin II receptor dimerization. We found no other in vivo studies in the literature regarding the effect of aldosterone on colocalization of AT1R and AT2R in whole kidney. Male Wistar rats were intraperitoneally injected with either normal saline solution (sham group) or aldosterone (experimental group). Colocalization of renal AT1R and AT2R proteins was examined by double immunohistochemical staining. The colocalization of AT1R and AT2R proteins was more prominent in the glomerulus, distal convoluted tubules, and cortical collecting ducts while colocalization was weak and diffused in the proximal convoluted tubules and peritubular capillaries in both groups. Our in vivo study showed aldosterone did not alter a constitutive colocalization of AT1R and AT2R proteins in the renal cortex and medulla. However, these proteins were colocalized more prominently in the renal cortex.
Keywords: Aldosterone, angiotensin II receptors, nongenomic action, protein colocalization, rat kidney
Link to Academic article: https://doi.org/10.1080/01478885.2018.1438756
Journal : ,
Bibliography : Sinphitukkul, K., Manotham, K., Eiam-Ong, S., & Eiam-Ong, S. (2018). Nongenomic action of aldosterone on colocalization of angiotensin II type 1 and type 2 receptors in rat kidney.
Nongenomic effect of aldosterone on angiotensin II type 1 receptor dimerization in human renal proximal tubular cells: Implications for endoplasmic reticulum stress (2018)
Title : Nongenomic effect of aldosterone on angiotensin II type 1 receptor dimerization in human renal proximal tubular cells: Implications for endoplasmic reticulum stress
Researcher : Sinphitukkul, K., Manotham, K., Eiam-Ong, S., …Inagi, R., Eiam-Ong, S.
Abstract : In vitro studies have showed that aldosterone increases oxidative stress molecules through a nongenomic effect. Oxidative stress induces angiotensin II type 1 receptor (AT1R) dimerization and endoplasmic reticulum (ER) stress, leading to renal tubular damage. However, the nongenomic effect of aldosterone on AT1R dimerization and ER stress in renal cells has not been determined. Here, we examined the nongenomic action of aldosterone in renal proximal tubular epithelial cells (PTECs) to better understand the underlying mechanisms. HK-2 cells, human renal PTECs, were exposed to vehicle or aldosterone for 30 min. In two additional groups, the cells were pretreated with eplerenone, a mineralocorticoid receptor (MR) blocker or apocynin, an NADPH oxidase inhibitor, for 30 min before aldosterone incubation. Protein abundances of dimeric/monomeric forms of AT1R, p47phox (a cytosolic part of NADPH oxidase), and activating transcription factor 4 (ATF4), a transcription factor responsive to ER stress, were determined by Western blotting. Aldosterone nongenomically increased plasma membrane protein expression of AT1R dimeric forms in a time- and dose-dependent manners. The levels of the cytosolic p47phox protein declined while the membranous protein level was enhanced following aldosterone treatment. The aldosterone induced alteration in these two proteins was abolished by pretreatment with eplerenone or apocynin. In addition, aldosterone (100 nM) induced nuclear ATF4 protein accumulation in a time-dependent fashion, which was blocked by apocynin and partially attenuated by eplerenone. Aldosterone nongenomically increased AT1R dimerization and nuclear ATF4 protein accumulation dependent on MR and NADPH oxidase activation. Hence aldosterone could induce AT1R dimerization and activate the endoplasmic reticulum stress response.
Link to Academic article: doi: 10.2306/scienceasia1513-1874.2018.44.332
Journal : ,
Bibliography : Sinphitukkul, K., Manotham, K., Eiam-Ong, S., Nangaku, M., Inagi, R. & Eiam-Ong, S. (2018). Nongenomic effect of aldosterone on angiotensin II type 1 receptor dimerization in human renal proximal tubular cells: Implications for endoplasmic reticulum stress.
Optimization of coconut protein deamidation using protein-glutaminase and its effect on solubility, emulsification, and foaming properties of the proteins (2018)
Title : Optimization of coconut protein deamidation using protein-glutaminase and its effect on solubility, emulsification, and foaming properties of the proteins
Researcher : Kunarayakul, S., Thaiphanit, S., Anprung, P., Suppavorasatit, I.
Department : ภาควิชาเทคโนโลยีการอาหาร คณะวิทยาศาสตร์ มหาวิทยาลัยสยาม
E-mail : somruedee.tha@siam.edu
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม: –
Link to article: Food Hydrocolloids, 2018, 79, pp. 197–207. https://doi.org/10.1016/j.foodhyd.2017.12.031
Journal : Food Hydrocolloids / in Scopus
Bibliography : Kunarayakul, S., Thaiphanit, S., Anprung, P., & Suppavorasatit, I. (2018). Optimization of coconut protein deamidation using protein-glutaminase and its effect on solubility, emulsification, and foaming properties of the proteins. Food Hydrocolloids, 79, 197–207. https://doi.org/10.1016/j.foodhyd.2017.12.031
Persistence of hepatitis B immune memory until 9-10 years of age following hepatitis B vaccination at birth and DTaP-IPV-HB-PRP∼T vaccination at 2, 4 and 6 months (2018)
Title : Persistence of hepatitis B immune memory until 9-10 years of age following hepatitis B vaccination at birth and DTaP-IPV-HB-PRP∼T vaccination at 2, 4 and 6 months
Researcher : Clin.Prof.Suwat Benjaponpitak
Department : Faculty of Medicine, Siam University, Bangkok, Thailand
E-mail : med@siam.edu
Abstract : Objective: To evaluate the long-term persistence of anti-hepatitis B surface (HBs) antibodies and the response to a HB challenge re-vaccination in children who had received a primary series of DTaP-IPV-HB-PRP∼T (Hexaxim™) or DTaP-IPV-HB/PRP∼T (Infanrix hexa™).
Methods: Two cohorts of participants who had previously received HB vaccine at birth followed by either DTaP-IPV-HB-PRP∼T or DTaP-IPV-HB/PRP∼T co-administered with PCV7 at 2, 4, 6 months of age in a randomized, Phase III, observer-blind study in Thailand, were followed up for anti-HBs antibodies (geometric mean concentrations [GMCs] and seroprotection [SP] rate [% of participants with a titer ≥10 mIU/mL]) at 12-18 months of age and 9-10 years of age. A monovalent HB challenge re-vaccination was administered at 9-10 years of age and the anamnestic response was evaluated.
Results: Anti-HBs GMCs and SP rates in the DTaP-IPV-HB-PRP∼T and DTaP-IPV-HB/PRP∼T groups were high and similar post-primary vaccination series (2477 mIU/mL and 99.5% and 2442 mIU/mL and 99.5%, respectively) and declined to a similar extent in each group at 12-18 months (154.5 mIU/mL and 90.8% and 162.3 mIU/mL and 96.5%, respectively). Antibody levels further declined at 9-10 years of age (13.3 mIU/mL and 49.3% and 8.0 mIU/mL and 42.9%) and a strong anamnestic response occurred in each group post-HB challenge re-vaccination (92.8% and 98.7%, respectively).
Conclusion: The kinetics of long-term anti-HBs antibody persistence were similar following a primary series of DTaP-IPV-HB-PRP∼T or DTaP-IPV-HB/PRP∼T. The response to a subsequent HB challenge re-vaccination was strong and similar in each group, demonstrating persisting immune memory.
Key words: Link to Academic article: fully liquid; hepatitis B; hexavalent; immunity persistence; infant; primary series; vaccine.
Journal : Human Vaccines & Immunotherapeutics
Bibliography : Kosalaraksa, P., Chokephaibulkit, K., Benjaponpitak, S., Pancharoen, C., Chuenkitmongkol, S., B’Chir, S., Da Costa, X., & Vidor, E. (2018, May 4). Persistence of hepatitis B immune memory until 9-10 years of age following hepatitis B vaccination at birth and DTaP-IPV-HB-PRP∼T vaccination at 2, 4 and 6 months. Hum Vaccin Immunother, 14(5), 1257-1265. doi: 10.1080/21645515.2018.1426418. Epub 2018 Feb 21. PMID: 29333947; PMCID: PMC5989896.
Reference value of Forced Oscillation Technique for healthy preschool children (2018)
Title : Reference value of Forced Oscillation Technique for healthy preschool children
Researcher : Clin.Prof.Suwat Benjaponpitak
Department : Faculty of Medicine, Siam University, Bangkok, Thailand
E-mail : med@siam.edu
Abstract : Background: The reference values of Forced Oscillation Technique (FOT) parameters of the inspiratory and expiratory phase for preschool children have not yet been established.
Objective: To evaluate FOT measures in Thai healthy preschool children.
Methods: Preschool children, aged 3-6 years, were screened. Children who were positive for the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for asthma, positive family history of allergic diseases, recent lower respiratory tract infections, and environmental tobacco smoke were excluded. FOT parameters, including resistance (Rrs), reactance (Xrs), frequency of resonance (Fres) and area of reactance (ALX), were measured.
Results: A total of 390 healthy children with the mean age of 5.1 ± 0.9 years were enrolled. FOT was successfully performed in 378 children (96.9%). The mean (SD) for the whole breath (WB) resistance at 5Hz (R5), 20 Hz (R20) and R5-20 were 11.49 (2.69) cmH2O/L/s, 9.46 (2.19) cmH2O/L/s and 2.02 (0.82) cmH2O/L/s, respectively. The median (IQR) for WB reactance at 5Hx (X5), Fres and ALX were -1.51 (-2.37 to -0.96) cmH2O/L/s, 11.17 (8.50-15.65) Hz, and 7.53 (3.72-14.32) cmH2O/L/s, respectively. Significantly difference in WB R5, R20, X5, Fres and ALX between male and female children were demonstrated. The expiratory phase R5, R20, R5-20 were significantly higher than those of the inspiratory phase (p < 0.001). There are significant correlations between the height and FOT parameters. Reference curve for the FOT parameters was generated based on height using the lambda-mu-sigma (LMS) method.
Conclusion: Reference curve of FOT parameters measured in healthy preschool children were demonstrated. Majority of preschool children could perform FOT method.
Key words: Respiratory resistance, Respiratory reactance, LMS method, Frequency of resonance, Area of reactance
Link to Academic article: DOI: 10.12932/AP-110618-0334
Journal : Asian Pacific journal of allergy and immunology
Bibliography : Mukdjindapa, P., Manuyakorn, W., Kiewngam, P., Sasisakulporn, C., Pongchaikul, P., Kamchaisatian, W., & Benjaponpitak, S. (2018, December 9). Reference value of Forced Oscillation Technique for healthy preschool children. Asian Pac J Allergy Immunol, doi: 10.12932/AP-110618-0334. Epub ahead of print. PMID: 30525741.
Role of Vitamin C and Vitamin E in Skin Health
Research Article : Role of Vitamin C and Vitamin E in Skin Health
Author : Thaompong Sathienluckana
Email : –
Department : Faculty of Pharmacy, Siam University, Bangkok 10160, Thailand
Published : The Medical News Volume 20, Issue 485, September 2018, Special reprint page between pages 28-29.
Bibliography :
Thaompong Sathienluckana. (2018, September). Role of Vitamin C and Vitamin E in Skin Health. The Medical News, 20(485), 1-8.
Safinamide กับการรักษาโรคพาร์กินสัน (2561)
Safinamide กับการรักษาโรคพาร์กินสัน (2561)
ผู้เขียนบทความ: อ.ภก. พิชัย ชัยชนะชัยชาญ
บทคัดย่อ:
โรคพาร์กินสันเป็นโรคความเสื่อมของเซลล์ประสาท (neurodegenerative disease) ที่พบมากเป็นอันดับสองของโลก ในปัจจุบันเชื่อว่าสาเหตุเกิดมาจากการตายของเซลล์ประสาทที่สร้างสารสื่อประสาทโดปามีน (dopaminergic neurons) ทำให้มีระดับของสารสื่อประสาทโดปามีนลดลง ส่งผลให้เกิดอาการแสดงทางคลินิก ได้แก่ อาการทางด้านการเคลื่อนไหว (motor symptoms) และอาการที่ไม่ใช่อาการด้านการเคลื่อนไหว (non-motor symptoms) ยา safinamide เป็นยาที่ได้รับการอนุมัติจากองค์การอาหารและยาแห่งสหรัฐอเมริกา(USFDA) โดยใช้เป็นยาเสริม (add-on therapy) แก่ผู้ป่วยที่ได้รับยา levodopa ขนาดคงที่และเกิด wearing off phenomenon ยา safinamide มีกลไกการออกฤทธิ์คือยับยั้งการทำงานของเอนไซม์ monoamine oxidase B แบบผันกลับได้ (reversible MAO-B inhibitor) ซึ่งมีข้อดี คือ มีความเลือกจับ (selectivity) ต่อ MAO-B มากกว่ายาอื่นๆ ในกลุ่ม และไม่จำเป็นต้องควบคุมการรับประทานยากับอาหารที่มีไทรามีนสูง นอกจากนี้ยังมีการศึกษาผลของยา safinamide ต่อการป้องกันการตายของเซลล์ประสาทในสัตว์ทดลอง (neuroprotective effects) ที่ถูกเหนี่ยวนำให้เป็นโรคพาร์กินสันด้วยสาร 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) อย่างไรก็ตามยา safinamide อาจจะมีฤทธิ์อื่นๆ เช่น ลดอาการปวด ลดอาการของโรคซึมเศร้าได้ เนื่องจากยามีกลไกการออกฤทธิ์อื่นๆ เช่น ยับยั้งการหลั่งกลูตาเมท (glutamate) ปิดกั้นตัวรับของโซเดียมไอออนและแคลเซียมไอออน (sodium and N-type calcium channels) ซึ่งยังต้องศึกษาในทางคลินิกต่อไปในอนาคต
คำสำคัญ: safinamide, Parkinson’s disease, MAO-B inhibitors
Link to Academic article: Safinamide กับการรักษาโรคพาร์กินสัน
Special Interest Tourism
Title : Special Interest Tourism
Authors : Bongkosh N. Rittichainuwat
Department : Service Industry Management, Siam University, Bangkok, Thailand
E-mail : Bongkosh N. Rittichainuwat ngamson@gmail.com
Description : This research-based textbook covers 15 chapters on food, film, shopping, medical, ghost, and suicide tourism, based on research conducted over 15 years on tourists from East Asia and Southeast Asia, the UK, the USA, Australia, Germany, and New Zealand. It introduces students, researchers, educators, tourist bureaus, and tour operators to the demands of affluent tourists from the newly industrialized countries of East Asia and Southeast Asia.
Link to E-book: Special Interest Tourism
Bibliography : Rittichainuwat, B. N. (2018). Special Interest Tourism (3rd ed.). Newcastle upon Tyne, UK: Cambridge Scholars Publishing.
Author details in Scopus: Rittichainuwat, Bongkosh Ngamsom
Google Scholar Citations: https://scholar.google.com/citations?user=ifUlKJoAAAAJ&hl=en
The effect of surfactant on the physical properties of coconut oil nanoemulsions
Abstract
The aim of this study was to develop the water compatible form of coconut oil through nano-emulsification. The effect of different types and amounts of surfactants on the physical characteristics of nanoemulsions containing coconut oil was investigated. Coconut oil nanoemulsions containing varied amounts of surfactants including polyethylene glycol octyl phenyl ether (PGO), polyoxyethylene sorbitan monostearate (POS), polyethylene glycol hydrogenated castor oil (PHC), sodium lauryl sulfate (SLS) and poloxamer 407 (PLX) were formulated and comparatively evaluated for their physical properties. The results showed that the coconut oil nanoemulsions using PGO, POS and PHC as surfactants exhibited low percent creaming index indicating excellent stability, while those containing SLS and PLX demonstrated the higher percent creaming index suggesting lesser physical stability. The droplet sizes of nanoemulsions consisting of 5% (w/w) PGO, POS and PHC were 22.843, 4.458 and 0.162 µm, respectively. Thus, coconut oil nanoemulsions with the smallest size could be obtained when PHC was applied. Furthermore, the droplet size of nanoemulsions decreased from 33 µm to less than 200 nm with an increase in the amount of PHC from 1% to 10% (w/w). Additionally, the properties of coconut oil based nanoemulsions containing PHC were not changed through temperature cycling test. From these results, it was suggested that the fabrication of stable coconut oil nanoemulsions with small particle size could be easily achieved by using 5% (w/w) PHC as a surfactant. The knowledge gained from the study might provide the basic guideline for the fabrication of stable nanoemulsions for food, cosmetic and pharmaceutical fields in the future.
Link to Publication: https://www.sciencedirect.com/science/article/pii/S1818087617308267
Bibliography :Sirikarn Pengon, Nawinda Chinatangkul, Chutima Limmatvapirat, Sontaya Limmatvapirat. (2018). The effect of surfactant on the physical properties of coconut oil nanoemulsions. Asian Journal of Pharmaceutical Sciences, 409-414.