HIV Vaccine Trials in Thailand and Path to HIV Cure (2022)
Title : HIV Vaccine Trials in Thailand and Path to HIV Cure
Researcher : Leelarasamee, A., Yoksan, S., Sutthent, R., Sirisinha, S., Siraprapasiri, T.
Department :
Abstract : Thailand has had over 30 years of experiences and development in fighting HIV/AIDS with successful results in terms of providing access to prevention, testing, antiretroviral treatment (ART) and care for over 90% of the affected patients. As a consequence, approximately 400,000 patients on ART currently have undetectable viral load, lead normal lives, and are untransmittable. However, ART must remain in place forever or else the viral load in blood will rebound. Recent advance in stem cell transplant, gene editing, and therapeutic HIV vaccine development yields hope on designing novel approach for an HIV elimination or functional cure. The National AIDS Prevention and Alleviation Committee of Thailand has set up the Subcommittee on HIV Vaccine Trials to oversee and endorse experimental vaccine regimen with sound and adequate scientific background to be tested in Thailand. So far, at least 23 small and large studies have been conducted in collaboration with the international organizations and at least 10 articles were published after the studies ended and cited over 2,726 times. One landmarked trial using notable vaccine regimen, evaluated in the RV144 trial, has shown effectiveness in reducing new infections by 31.2%. The conduction of these research in Thailand have facilitated the development of infrastructure, networking, and experience sufficiently to further support future field trial with a notable HIV cure approach. Since there are over 400,000 HIV cases with undetectable viral load in Thailand, this condition poses an excellent opportunity for testing a novel HIV cure approaches to eliminate HIV or functional HIV cure. The Subcommittee has reviewed current novel methods in this regard and strongly welcomed international organizations with similar aim, to test an innovative therapeutic HIV vaccine or a combination therapy to finally end HIV/AIDS in Thailand by the year 2030.
Keywords: HIV vaccine; HIV cure; Latent HIV reservoir; mRNA vaccine; Gene therapy; Stem cell transplantation
Link to Academic article: DOI: 10.35755/jmedassocthai.2022.11.13707
Journal : ,
Bibliography : Leelarasamee, A., Yoksan, S., Sutthent, R., Sirisinha, S., & Siraprapasiri, T. (2022). HIV Vaccine Trials in Thailand and Path to HIV Cure.
Homocysteine and Lipid Peroxidation in Active and Passive Smoking (2018)
Title : Homocysteine and Lipid Peroxidation in Active and Passive Smoking
Researcher : Duangkamol Viroonudomphol, Faculty of Nursing, Siam University, Bangkok, Thailand
Pornpimon Poomrittikul, Faculty of Nursing, Siam University, Bangkok, Thailand
Tharntip Jirakanjana, Faculty of Nursing, Siam University, Bangkok, Thailand
Siriwan Tribanyatkul, Pramongkutklaw Hospital, Bangkok, Thailand
Saowanee Kanjanachumpon, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Department : Faculty of Nursing, Siam University, Bangkok, Thailand
E-mail : v_duangkamol@yahoo.com
Abstract : Disease risk due to smoking is not limited to smokers only. Passive smoking (exposure to environmental tobacco smoke) is associated with adverse health effect especially in cardiovascular disease. Side-stream cigarette smoke, a major component of secondhand smoke induces reactive oxygen species with promote oxidative stress. This paper summarizes the cardiovascular effects of tobacco smoke. According to the results of the alternative level of biochemistry substances, Cholesterol (C), HDL- Cholesterol (HDL-C), LDL-Cholesterol (LDL-C), Triglyceride (TG), Malondialdehyde (MDA), Conjugate diene (CD), vitamin B12, folate and Homocysteine (Hcy). The results showed that vitamin B12 and Hcy of smokers were significantly higher than those of non-smokers while C, LDL-C, TG and folate were significantly lower than those of non-smokers. More detail of smoking group, the industrial tobacco smokers had HDL-C and vitamin B12 lower than those in non-smokers whereas passive smokers and local handmade tobacco smokers had serum HDL-C and vitamin B12 higher than those in non-smokers. For serum C, LDL-C, TG and folate of all groups of smokers were significantly lower than non-smokers. The industrial tobacco smokers had serum MDA significantly higher than non-smokers but passive smokers and local handmade tobacco smokers had serum MDA lower than non-smokers. The industrial tobacco smokers and passive smokers had serum Hcy significantly higher than non-smokers but local handmade tobacco smokers had serum Hcy lower than non-smokers.
Keywords : Homocysteine, Lipid Peroxidation, Active and Passive Smoking
Journal : Science Journal of Public Health, 6(2), 43-49 : DOI:10.11648/j.sjph.20180602.12
Bibliography : Duangkamol Viroonudomphol, Pornpimon Poomrittikul, Tharntip Jirakanjana, Siriwan Tribanyatkul, & Saowanee Kanjanachumpon. (2018). Homocysteine and Lipid Peroxidation in Active and Passive Smoking. Science Journal of Public Health, 6(2), 43-49. doi: 10.11648/j.sjph.20180602.12
Homocysteine, Vitamin B12 and Folic Acid in Children with Acute Glomerulonephritis (2018)
Title : Homocysteine, Vitamin B12 and Folic Acid in Children with Acute Glomerulonephritis
Researcher : 1.Duangkamol Viroonudomphol, 2.Saowanee Kanjanachumpol, 3.Sarinya Sirisate
Department : 1.Faculty of Nursing, Siam University, Bangkok, Thailand
2.Faculty of Medicine Ramathibody Hospital, Mahidol University, Bangkok, Thailand
3.Department of Pediatrics, Faculty of Medicine Ramathibody Hospital, Mahidol University, Bangkok, Thailand
E-mail : v_duangkamol@yahoo.com
Abstract : Homocysteine (Hcy) is an intermediate product of methionine formed by its demethylation. Hcy can be metabolized via remethylation to methionine or transsulfuration to cysteine which is dependent on several enzymes and co-factors. It is deleterious to blood vessel including glomeruli. Kidney is a major organ that metabolizes Hcy. More than 80% of patients with chronic renal disease develop hyperhomocysteinemia (hHcy). Accessible data of plasma Hcy in nephritic syndrome (NS) patients are controversial with increased, decreased and unchanged values reported. In renal patients, plasma Hcy concentration can be reduced by administration of folic acid. Absolute or rel-ative deficiencies of folate, vitamin B6, or vitamin B12 may also play a role. Therefore, plasma Hcy, folic acid, vitamin B6, and vitamin B12 in children with acute glomerulonephritis (AGN) were accessed in this study. Hcy, folic acid vitamin B12, B6 and renal function such as blood urea itrogen (BUN), creatinine (Cr) were analyzed 12 pediatric patients with AGN and 15 age and sex matched healthy children served as controls. The results revealed that a significant increase in plasma Hcy in children with acute AGN when com-pared with controls. For simple regression analysis, Hcy was positively corre-lated with BUN, Cr, ferritin and uric acid but negatively correlated with serum glutathione. This research indicated hHcy suggests enhanced risks for inflam-mation and endothelial injury, which lead to kidney disease. Folic acid has also been shown to improve endothelial function, suggesting an alternative expla-nation for the effect of folic acid on endothelial function. Careful considera-tions of not only dietary measures are necessary but also folate and vitamin B supplementation for reducing hHcy in AGN need to be investigated.
Keywords : Folic Acid, Homocysteine, Hyperhomocysteinemia, Acute Glomerulonephriti
Journal : World Journal of Engineering and Technology, 6(3), 661-670. : https://doi.org/10.4236/wjet.2018.63042
Link to Full-Text PDF: https://www.scirp.org/pdf/WJET_2018080915421290.pdf
Bibliography : Viroonudomphol, D. , Kanjanachumpol, S. & Sirisate, S. (2018) Homocysteine, Vitamin B12 and Folic Acid in Children with Acute Glomerulonephritis. World Journal of Engineering and Technology, 6(3), 661-670. doi: 10.4236/wjet.2018.63042.
Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations (2021)
Title : Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations
Researcher : Dhakrit Rungkitwattanakul, Taniya Charoensareerat, Pathakorn Kerdnimith, Nutsinee Kosumwisaisakul, Piyakamol Teeranaew, Apinya Boonpeng, Sutthiporn Pattharachayakul, Nattachai Srisawat and Weerachai Chaijamorn
Link to article: Renal Replacement Therapy Vol. 7, Article number: 61 (2021) Page.1-11. https://doi.org/10.1186/s41100-021-00380-6
Citation : Rungkitwattanakul D., Charoensareerat T., Kerdnimith P., Kosumwisaisakul N., Teeranaew P.,Boonpeng A…Chaijamorn W. (2021). Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: Systematic review and Monte Carlo simulations. Renal Replacement Therapy, 7(61), 1-11. https://doi.org/10.1186/s41100-021-00380-6
Journal : Renal Replacement Therapy / in Scopus
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : https://e-research.siam.edu/kb/imipenem-dosing-recommendations-for-patients/
Impact of inappropriate empiric antimicrobial therapy on mortality of septic patients with bacteremia: A retrospective study(2012)
Title : Impact of inappropriate empiric antimicrobial therapy on mortality of septic patients with bacteremia: A retrospective study
Researcher : Lueangarun, S., Leelarasamee, A.
Department : [mfn]1[/mfn]Department of Medicine, Chulabhorn Hospital, Lak Si, Bangkok 10210, Thailand
[mfn]2[/mfn]Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Abstract : Background. Inappropriate empiric antimicrobials could be a major cause of unfavorable mortality rates in co-morbid patients. This study aimed to assess the prevalence and impact of first-dose and 24-hour inappropriate antimicrobials on mortality rates of bacteremic septic patients. Methods. A retrospective cohort study was employed. Case record forms of patients diagnosed as sepsis, severe sepsis, or septic shock with positive hemoculture during 2009 were retrieved from the medical wards, Siriraj Hospital. Demographic data, antimicrobial use, types of bacteria isolated from blood and susceptibilities, patients’ comorbidities, 28-day and overall mortality rates were collected and analyzed. Results. There were 229 cases, mean age (SD) of 63.5 (17.2) years and mean (SD) APACHE II score of 24.7 (6.8). The prevalence of first-dose and 24-hour inappropriate antimicrobials was 29.7% and 25.3%, respectively. The 28-day and overall mortality rates between first-dose inappropriate and appropriate antimicrobial were 67.6% versus 60.2% () and 75.0% versus 68.3% (), consequently. Patients with septic shock and inappropriate first-dose antimicrobials significantly had higher 28-day mortality rate (61.6% versus 41.9%; ). Conclusion. Higher mortality rates in bacteremic septic patients were substantially associated with inappropriate first-dose antimicrobials and 3-hour delayed antimicrobial administration after sepsis diagnosis.
Link to Academic article: https://www.hindawi.com/journals/ipid/2012/765205/
Journal : Interdisciplinary Perspectives on Infectious Diseases
Bibliography : Lueangarun, S., & Leelarasamee, A. (2012). Impact of inappropriate empiric antimicrobial therapy on mortality of septic patients with bacteremia: A retrospective study. Interdisciplinary Perspectives on Infectious Diseases
Impacts of Climate Change on Rainfall Erosivity in the Huai Luang Watershed (2017)
Title : Impacts of Climate Change on Rainfall Erosivity in the Huai Luang Watershed
Researcher : Pheerawat Plangoen and Parmeshwar Udmale
Department : Department of Civil Engineering, Faculty of Engineering, Siam University, Bangkok, Thailand
Email : pheerawat.pla@siam.edu
Abstract : This study focuses on the impacts of climate change on rainfall erosivity in the Huai Luang watershed, Thailand. The multivariate climate models (IPCC AR5) consisting of CCSM4, CSIRO-MK3.6.0 and MRI-CGCM3 under RCP4.5 and RCP8.5 emission scenarios are analyzed. The Quantile mapping method is used as a downscaling technique to generate future precipitation scenarios which enable the estimation of future rainfall erosivity under possible changes in climatic conditions. The relationship between monthly precipitation and rainfall erosivity is used to estimate monthly rainfall erosivity under future climate scenarios. The assessment compared values of rainfall erosivity during 1982–2005 with future timescales (i.e., the 2030s, 2050s, 2070s and 2090s). The results indicate that the average of each General Circulation Model (GCM) combination shows a rise in the average annual rainfall erosivity for all four future time scales, as compared to the baseline of 8302 MJ mm ha−1 h−1 year−1, by 12% in 2030s, 24% in 2050s, 43% in 2070s and 41% in 2090s. The magnitude of change varies, depending on the GCMs (CCSM4, CSIRO-MK3.6.0, and MRI-CGCM3) and RCPs with the largest change being 82.6% (15,159 MJ mm ha−1 h−1 year−1) occurring under the MRI-CGCM3 RCP8.5 scenario in 2090s. A decrease in rainfall erosivity has been found, in comparison to the baseline by 2.3% (8114 MJ mm ha−1 h−1 year−1) for the CCSM4 RCP4.5 scenario in 2030s and 2.6% (8088 MJ mm ha−1 h−1 year−1) for the 2050s period. However, this could be considered uncertain for future rainfall erosivity estimation due to different GCMs. The results of this study are expected to help development planners and decision makers while planning and implementing suitable soil erosion and deposition control plans to adapt climate change in the Huai Luang watershed.
Key words : climate change; rainfall erosivity; precipitation; soil erosion; sedimentation
Link to article : Atmosphere Vol.8 No.8 Aug 2017, pp.1-18. https://doi.org/10.3390/atmos8080143
Journal : Atmosphere / in Scopus
Bibliography : Pheerawat Plangoen & Parmeshwar Udmale. (2017). Impacts of Climate Change on Rainfall Erosivity in the Huai Luang Watershed. Atmosphere, 8(8), 1-18. https://doi.org/10.3390/atmos8080143
Improvement of organic red pigment prodcution by Monascus Purpureus TISTR3651 using pathumthani-1 rice-based medium in submerged and solid-state fermentation (2021)
Title : Improvement of organic red pigment prodcution by Monascus Purpureus TISTR3651 using pathumthani-1 rice-based medium in submerged and solid-state fermentation
Researcher : Techaoei, S., Jarmkom, K., Dumrongphuttidacha, T., Khobjai, W.
Department :
Abstract : Objective: This research is to study the production of natural red pigment by Monascus purpureus TISTR3615 in the submerged and solid-state
fermentation system using Pathumthani-1 rice as a carbon source.
Methods: The antioxidant activity of the red pigment was evaluated in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS radical scavenging assay,
and ferric-reducing antioxidant power (FRAP) assay, including total phenolic compound.
Results and Discussion: The maximum of red pigment production was 0.55±0.02/ml (OD 680 nm) after incubation at 30°C for 24 days. The
antioxidant activity based on inhibition DPPH (%), ABTS radical scavenging activity (%), and FRAP activity (mM Fe2+/g) was 97.80±1.51,
68.64±0.46, and 0.32±0.021, respectively. The total phenolic content was 164.78±2.82 μg GAE/mg.
Conclusion: It was estimated that Monascus pigments, leading to nutraceutical and pharmaceutical applications, cosmetic industry, and food
industry.
Keywords: Natural pigment, Monascus purpureus, Submerged fermentation, Solid-state fermentation, Agricultural product
Link to Academic article: DOI: https://doi.org/10.22159/ijap.2021.v13s1.Y0103
Journal : ,
Bibliography : Techaoei, S., Jarmkom, K., Dumrongphuttidacha, T., & Khobjai, W. (Improvement of organic red pigment prodcution by Monascus Purpureus TISTR3651 using pathumthani-1 rice-based medium in submerged and solid-state fermentation. , Retrieved from https://doi.org/10.22159/ijap.2021.v13s1.Y0103
Improvement of solubility, foaming, and emulsification properties of coconut (Cocos nucifera L.) protein by non-enzymatic deamidation (2022)
Title : Improvement of solubility, foaming, and emulsification properties of coconut (Cocos nucifera L.) protein by non-enzymatic deamidation
Researcher : Meenmanee, S., Rattananukrom, A., Thaiphanit, S., Suppavorasatit, I.
Department : ภาควิชาเทคโนโลยีการอาหาร คณะวิทยาศาสตร์ มหาวิทยาลัยสยาม
E-mail : somruedee.tha@siam.edu
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม:
Link to article: LWT-Food Science and Technology, Vol.153 (2022), page 112493. https://doi.org/10.1016/j.lwt.2021.112493
Journal : LWT / in Scopus
Bibliography : Meenmanee, S., Rattananukrom, A., Thaiphanit, S., & Suppavorasatit, I.(2022). Improvement of solubility, foaming, and emulsification properties of coconut (Cocos nucifera L.) protein by non-enzymatic deamidation. LWT-Food Science and Technology, 153, 112493. https://doi.org/10.1016/j.lwt.2021.112493
Improving the Flavor of Soy Ice Cream by Adding Lemongrass or Pandan Leaf Extracts (2014)
Title : Improving the Flavor of Soy Ice Cream by Adding Lemongrass or Pandan Leaf Extracts
Researcher : Sirinat Natisri, Kanjana Mahattanatawee*, Siwatt Thaiudom
Department : *Food Technology Department, Faculty of Science, Siam University
E-mail : *kanjana@siam.edu
Abstract : Lemongrass or pandan leaf extracts were used separately to improve the flavor of soy ice cream. Lemongrass or pandan leaf extracts with water in concentrations of 10: 100, 15: 100, and 20: 100 w/w were examined using sensory evaluation for the best flavor acceptance. The best ratio was selected to spray dry using maltodextrin as the drying medium at various concentrations (2, 4, 6, 8 and 10% w/w). A ranking preference test was used to determine the flavor of the soy ice cream. Threshold testing was used to determine the sensorial quality of soy isolate protein mixed with both herb extracts, and soy ice cream mixed with both herb extracts. The flavor compound was analyzed by using headspace, solid-phase microextraction, gas chromatography, mass spectrophotometry (HSSPME-GC-MS). The best concentration of fresh lemongrass or pandan leaf extracts for improving the sensorial flavor of soy ice cream was 10: 100 (w/w). The optimum quantity of maltodextrin for spray drying was 2%(w/w). The threshold values of fresh and powdered lemongrass extracts that could mask the beany flavor in soy protein isolate solution and soy ice cream were lower than those of fresh and powdered pandan leaf extracts. The beany flavor in soy protein isolate solution and soy ice cream was mainly composed of hexanal, pentanal, benzaldehyde, 2-pentyl-furan and 1-octen-3-ol. The flavor compounds in pandan leaf extract were 2-acetyl-1-pyroline and 3-methyl-2 (5H)-furanone, while those of lemongrass extract were β-myrcene, α-pinene, 3-carene, neral, geranial and geraniol. From the results of HS-SPME-GC-MS, the beany flavor was masked by these extracts. This indicated that lemongrass and pandan leaf extracts could mask the beany flavor and improve the sensorial quality of soy ice cream.
Keywords: Ice cream, Lemongrass, Pandan leaf, Beany flavor, Headspace, Solidphase microextraction, Gas-chromatography, Mass spectrophotometry
Link to Publication: CHIANG MAI UNIVERSITY JOURNAL OF NATURAL SCIENCES/Natural and Life Sciences Communications Volume 13, Issue 01(S) DECEMBER 2014
Bibliography : Natisri, S., Mahattanatawee, K., & Thaiudom, S. (2014). Improving the flavor of soy ice cream by adding lemongrass or Pandan leaf extracts. Chiang Mai University Journal of Natural Sciences, 13(1 s), 469-482.
In vitro activities of colistin and sitafloxacin combinations against multidrug-, carbapenem-, and colistin-resistant acinetobacter baumannii using the broth microdilution checkerboard and time-kill methods (2020)
Title : In vitro activities of colistin and sitafloxacin combinations against multidrug-, carbapenem-, and colistin-resistant acinetobacter baumannii using the broth microdilution checkerboard and time-kill methods
Researcher : Rodjun, V., Houngsaitong, J., Montakantikul, P., Paiboonvong, T., Khuntayaporn, P., Yanyongchaikit, P., & Sriyant, P.
ฐานข้อมูลงานวิจัย มหาวิทยาลัยสยาม : –
Link to article: Antibiotics, 2020, 9(8), pp. 1–10, 516. https://www.mdpi.com/2079-6382/9/8/516
Journal : Antibiotics / Scopus
Citation : Rodjun, V., Houngsaitong, J., Montakantikul, P., Paiboonvong, T., Khuntayaporn, P., Yanyongchaikit, P., & Sriyant, P. (2020). In Vitro Activities of Colistin and Sitafloxacin Combinations against Multidrug-, Carbapenem-, and Colistin-Resistant Acinetobacter baumannii Using the Broth Microdilution Checkerboard and Time-Kill Methods. Antibiotics, 9(8), 516. https://doi.org/10.3390/antibiotics9080516